Selenium Metallicum

Selenium Metallicum Uses, Dosage, Side Effects, Food Interaction and all others data.

Selenium Metallicum is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species

Selenium Metallicum is incorporated into many different selenoproteins which serve various functions throughout the body .

Trade Name Selenium Metallicum
Availability Rx and/or OTC
Generic Selenium
Selenium Other Names Selen, Selenio, Sélénium, Selenium elemental, Selenium metallicum, Selenium, elemental
Related Drugs ferrous sulfate, folic acid, ergocalciferol, thiamine, Zinc
Type
Formula Se
Weight Average: 78.96
Monoisotopic: 79.916521828
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Selenium Metallicum
Selenium Metallicum

Uses

Selenium Metallicum is an ingredient found in a variety of supplements and vitamins.

For the supplementation of total parenteral nutrition to prevent hyposelenemia .

Selenium Metallicum is also used to associated treatment for these conditions: Nutritional supplementation

How Selenium Metallicum works

Selenium Metallicum is first metabolized to selenophosphate and selenocysteine. Selenium Metallicum incorporation is genetically encoded through the RNA sequence UGA . This sequence is recognized by RNA ste loop structures called selenocysteine inserting sequences (SECIS). These structures require the binding of SECIS binding proteins (SBP-2) to recognize selenocystiene. The specialized tRNA is first bound to a serine residue which is then enzymatically processed to a selylcysteyl-tRNA by selenocystiene sythase using selenophosphate as a selenium donor. Other unidentified proteins are required as part of the binding of this tRNA to the ribosome. Selenoproteins appear to be necessary for life as mice with the specialized tRNA gene knocked out exhibited early embryonic lethality .

The most important selenoproteins seem to be the glutathione peroxidases and thioredoxin reductases which are part of the body's defenses againts reactive oxygen species (ROS) . The importance of selenium in these anti-oxidant proteins has been implicated in the reduction of atherosclerosis by preventing the oxidation of low density lipoprotein . Selenium Metallicum supplementation is also being investigated in the prevention of cancer and has been suggested to be beneficial to immune function .

Toxicity

Oral LD50 of 6700mg/kg in rats . Selenium Metallicum exposure is teratogenic and can result in fetal death as tested in mice. Chronic toxicity is characterized by hair loss, white horizontal streaking on fingernails, paronchyia, fatigue, irritability, hyperreflexia, nausea, vomiting, garlic odor on breath, and metallic taste . Serum selenium correlates weakly with symtoms. Blood chemistry as well as liver and kidney function are normally unnaffected. Acute toxicity presents as stupor, respiratory depression, and hypotension. ST elevations and t-wave changes characteristic of myocardial infarction may be observed.

Food Interaction

No interactions found.

Selenium Metallicum Disease Interaction

Moderate: renal dysfunction, malabsorption syndromes

Elimination Route

Oral bioavailability of 90% when given as L-selenomethionine . Tmax of 9.17h.

Half Life

Half life was observed to increase with chronic dosing time . For day 1-2 half life was 1.7 days. For day 2-3 half life was 3 days. For day 3-14 half life was 11.1 days.

Elimination Route

Mainly excreted in urine as 1beta-methylseleno-N-acetyl-d-galactosamine and trimethylselenonium . The amount excreted as 1beta-methylseleno-N-acetyl-d-galactosamine plateaus at doses around 2microg after which the amount excreted as trimethylselenonium increases. Some selenium is also excreted in feces when given orally .

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