Sennagen
Sennagen Uses, Dosage, Side Effects, Food Interaction and all others data.
Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil.
Sennagen A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Senna stimulates peristalsis and increases fecal water content to increase motility of feces through the large intestine.
| Trade Name | Sennagen |
| Generic | Sennosides |
| Sennosides Other Names | Senna glycosides, Sennoside, Sennosides |
| Type | Tablet, coated |
| Formula | C42H38O20 |
| Weight | Average: 862.746 Monoisotopic: 862.195643624 |
| Protein binding | Because sennosides are ingested and their action occurs in the gut, it is generally not thought to be protein bound. |
| Groups | Experimental |
| Therapeutic Class | Osmotic purgatives |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
It is used to treat hard stools (constipation).
Sennagen is also used to associated treatment for these conditions: Constipation, Hemorrhoids, Auto-intoxication, Meteorism
How Sennagen works
Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone Rheinanthrone. Rheinanthrone Rheinanthrone appears to increase cyclooxegenase 2 (COX2) expression in macrophage cells leading to an increase in prostaglandin E2 (PGE2). This increase in PGE2 is associated with a decrease in aquaporin 3 expression in mucosal epithelial cells of the large intestine. A decrease in aquaporin 3 expression likely produces the laxative effect by restricting water reabsorption by the large intestine thereby increasing fecal water content. The exact mechanism by which rheinanthrone increases COX2 expression is unknown. Rheinanthrone Rheinanthrone also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown. Rhein Rhein, another active metabolite is thought to excite submucosal acetylcholinergic neurons resulting in increased chloride and prostaglandin secretion. The movement of chloride ions into the large intestine would also help to draw water into the lumen.
Dosage
Sennagen dosage
Constipation
- Adult: 15-30 mg (as total sennosides) 1-2 times daily.
- Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime.
Bowel evacuation
- Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
Side Effects
Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
Toxicity
Senna causes increased amounts of apoptosis in the large intestine shortly after use due to upregulated p53 activity. This is normally reversed after 18 hours however chronic use has been shown to be associated with p53 resistance and potential carcinogenicity leading to colon cancer. The LD50 value in rats was 5000mg/kg. Subacute studies in rats receiving 20mg/kg and dogs receiving 500mg/kg did not produce signs of toxicity. Tests for mutagenicity and reproductive toxicity do not indicate toxic effects.
Sennagen are not recommended for use in pregnancy due to genotoxic risks associated with chemically similar compounds. The active metabolite of sennosides is excreted in breast milk, though there are no reports of the laxitive effect in breast fed babies. There is no data on the effects of sennosides on fertility.
Precaution
Inflammatory bowel disease. Avoid prolonged use.
Food Interaction
- Avoid natural licorice. Licorice root can induce hypokalemia in patients taking sennosides.
Volume of Distribution
The volume of distribution of radiolabelled intravenous sennoside B in rats was 0.802±0.124L/kg.
Elimination Route
12.
Half Life
The half life of radiolabelled intravenous sennoside B in rats was 8.568±0.651h.
Clearance
The clearance of radiolabelled intravenous sennoside B in rats was 0.065±0.007L/h/kg.
Elimination Route
3-6% of metabolites are excreted in urine with some in bile. >90% of sennosides are excreted in the feces as polymers with 2-6% of the parent compounds excreted unchanged.
Pregnancy & Breastfeeding use
Sennagen has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Sennagen should only be given during pregnancy when benefits outweigh risks.
Sennagen is not excreted into human milk. However, Sennagen is a prodrug which is metabolized in vivo to the active sennosides (glucosides of rhein). Rhein is excreted into human milk in very small amounts. No adverse effects have been observed in nursing infants. The American Academy of Pediatrics considers Sennagen to be compatible with breast-feeding.
Contraindication
Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
Innovators Monograph
You find simplified version here Sennagen
FAQ
What is Sennagen used for?
Sennagen used to treat constipation.They work by keeping water in the intestines, which helps to cause movement of the intestines.
How safe is Sennagen?
Sennagen is likely safe for most adults and children over age 2 when taken by mouth, short-term.Sennagen can cause some side effects including stomach discomfort, cramps, and diarrhea.Sennagen is possibly unsafe when taken by mouth long-term or in high doses.
How does Sennagen work?
Sennagen work by keeping water in the intestines, which helps to cause movement of the intestines.
What are the common side effects of Sennagen?
Common side effects of Sennagen are include:
- Stomach/abdominal pain or cramping, nausea, diarrhea, or weakness may occur. ...
- This medication may cause your urine to turn reddish-brown.
How much Sennagen is too much?
Sennagen takes 34.4 mg per day.
Is Sennagen safe during pregnancy?
Sennagen may not be suitable if you're pregnant. Constipation is common at the end of pregnancy . If you're pregnant it is better to ease constipation without taking a medicine.
Is Sennagen safe during breastfeeding?
Usual doses of Sennagen are acceptable to use during breastfeeding.
Can I drink alcohol with Sennagen?
Yes, you can drink alcohol with Sennagen.
When is the best time to take Sennagen?
Sennagen may be best to take this medicine at night or at bedtime.
How quickly do Sennagen work?
Sennagen takes about 8 hours to work. It's best to take Sennagen at bedtime so it works overnight.
How to use Sennagen?
Take Sennagen by mouth as directed by your doctor. If you are self-treating, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Can I take Sennagen for a long time?
Sennagen is possibly unsafe when taken by mouth long-term or in high doses. Don't use Sennagen for more than two weeks.
How often can I take Sennagen?
Sennagen usually not more than 4 tablets two times a day.
Can I take Sennagen everyday?
You shouldn't use it for more than 7 consecutive days unless otherwise directed by your healthcare provider. Long-term Sennagen tea intake may lead to laxative dependence, electrolyte disturbances, and liver damage.
Why do you take Sennagen at night?
Sennagen normally causes a bowel movement within 6 to 12 hours, so it may be taken at bedtime to produce a bowel movement the next day.
Is Sennagen safe for kidneys?
Sennagen tablets or liquid are safe to use if you have kidney disease and you're constipated.
What happen If I missed Sennagen?
If your doctor has directed you to take this medication on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Can I overdose on Sennagen?
If someone has overdosed and has serious symptoms such as passing out or trouble breathing call a poison control center right away. Symptoms of overdose may include: severe stomach/abdominal pain or cramping, persistent nausea/vomiting/diarrhea.
