Sermion 1%
Sermion 1% Uses, Dosage, Side Effects, Food Interaction and all others data.
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Sermion 1% is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Sermion 1% also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
| Trade Name | Sermion 1% |
| Generic | Nicergoline |
| Nicergoline Other Names | Nicergolin, Nicergolina, Nicergoline, Nicergolinum |
| Type | |
| Formula | C24H26BrN3O3 |
| Weight | Average: 484.386 Monoisotopic: 483.11575436 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Japan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sermion 1% is an ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities.
For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Sermion 1% is also used to associated treatment for these conditions: Stroke, Ischemic, Transient Ischemic Attack, Peripheral vasodilatation
How Sermion 1% works
Sermion 1% acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Sermion 1% is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
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