Sheep Corticotropin-releasing Factor (1-41)

Sheep Corticotropin-releasing Factor (1-41) Uses, Dosage, Side Effects, Food Interaction and all others data.

Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary to release ACTH.

It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion. It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ectopic ACTH syndrome (an ectopic source of ACTH excess). If corticorelin injection results in an increase of plasma ACTH and cortisol, the patient is diagnosed with Cushing's disease. However, if corticorelin injection does not result in an increase of plasma ACTH and cortisol, the patient is diagnosed with ectopic ACTH syndrome.

In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides β- and γ-lipotropins (β -and γ-LPH) and β-endorphin (β -END).

Sheep Corticotropin-releasing Factor (1-41)
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Sheep Corticotropin-releasing Factor (1-41)
Generic	Corticorelin ovine triflutate
Corticorelin ovine triflutate Other Names	Corticorelin ovine, Corticorelin ovine triflutate, Corticorelin triflutate, Corticotropin-releasing factor (sheep hypothalamus), Corticotropin-releasing factor (sheep), Ovine ACTH releasing factor, Ovine corticotropin-releasing factor, Ovine CRF 41, Ovine CRH, Sheep corticotropin-releasing factor, Sheep corticotropin-releasing factor (1-41)
Type
Formula	C₂₀₅H₃₃₉N₅₉O₆₃S
Weight	Average: 4670.38 Monoisotopic: 4667.485744386
Protein binding	Corticorelin does not appear to be bound specifically by a circulating plasma protein.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Sheep Corticotropin-releasing Factor (1-41) is a synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Sheep Corticotropin-releasing Factor (1-41) is also used to associated treatment for these conditions: Pituitary-dependent Cushing's syndrome

How Sheep Corticotropin-releasing Factor (1-41) works

Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

Toxicity

The severity of adverse effects to a corticorelin injection appear to be dose-dependent. Dosages above 1 mcg/kg are not recommended. While few adverse effects have been observed at the 1 mcg/kg or 100 mcg dose, higher doses have been associated with transient tachycardia, decreased blood pressure, loss of consciousness, and asystole.

Food Interaction

No interactions found.

Volume of Distribution

The mean volume of distribution for IR-corticorelin is 6.2 ± 0.5 L

Elimination Route

Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of ≥0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes.