Sicorten Plus
Sicorten Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Halometasone is a topical corticosteroid with glucocorticoid activity. It exhibits anti-inflammatory and immunosuppressive effects by inhibiting the release of various cytokines.
Triclosan, a chlorinated bisphenol antiseptic, is active against fungi, gram-positive and gram-negative bacteria.
| Trade Name | Sicorten Plus |
| Generic | Halometasone + Triclosan |
| Weight | 05%+0.1% |
| Type | Cream |
| Therapeutic Class | Other Topical corticosteroids |
| Manufacturer | Novartis (Bangladesh) Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acne vulgaris, Corticosteriod-responsive dermatoses
Sicorten Plus is also used to associated treatment for these conditions: Corticosteroid responsive, Inflammatory DermatosisAcne, Dental Cavity, Dermabrasion, Gingivitis, Oral Infection, Plaque, Dental, Skin Infections, Bacterial, Abrasions, Minor burns, Antibacterial therapy, Antibiotic pre-surgical prophylaxis
How Sicorten Plus works
Triclosan is a biocidal compound with multiple targets in the cytoplasm and membrane. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to enoyl-acyl carrier protein reductase enzyme (ENR). This complex has increased affinity for NAD+ and forms a ternary complex. This complex is unable to participate in fatty acid synthesis, weakening the cell membrane and causing cell death. Humans do not have an ENR enzyme, and thus are not affected.
Dosage
Sicorten Plus dosage
Apply on affected areas as directed.
Apply on affected areas as directed.
Side Effects
Contact dermatitis.
Toxicity
Oral LD50, Rat: 3700 mg/kg; Dermal LD50, Rabbit: 9300 mg/kg
Precaution
Risk of systemic absorption when applied to large areas, broken skin or under occlusive dressings.
Elimination Route
A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream. [PMID: 10722890] Triclosan is rapidly absorbed and distributed in the human body (Sandborgh-Englund et al., 2006). Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.
Half Life
The terminal plasma half life of triclosan is 21 h (Sandborgh-Englund et al., 2006).
Elimination Route
In one study, after in vivo topical application of a 64.5mM alcoholic solution of [(3)H]triclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application. [PMID: 10722890]
Pregnancy & Breastfeeding use
Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category
Contraindication
Hypersensitivity.
Storage Condition
Should be stored in cool and dry place
Innovators Monograph
You find simplified version here Sicorten Plus
