Silece

Silece Uses, Dosage, Side Effects, Food Interaction and all others data.

Silece is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Silece is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug. It has however been approved in the United Kingdom and other countries.

Table Of contents

• Silece
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Silece
Generic	Flunitrazepam
Flunitrazepam Other Names	Flunitrazepam, Flunitrazepamum
Type
Formula	C16H12FN3O3
Weight	Average: 313.2832 Monoisotopic: 313.08626947
Groups	Approved, Illicit
Therapeutic Class
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Silece is a benzodiazepine used to manage anxiety disorders and insomnia.

For short-term treatment of severe insomnias, that are not responsive to other hypnotics.

Silece is also used to associated treatment for these conditions: Anxiety, Insomnia

How Silece works

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Toxicity

Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.

Food Interaction

• Avoid alcohol.
• Avoid grapefruit products.
• Limit caffeine intake.
• Take with food.

Elimination Route

50% (suppository) and 64-77% (oral)

Half Life

18-26 hours

Innovators Monograph

You find simplified version here Silece