Simplovir Tablet 200 mg

Simplovir Tablet 200 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Simplovir Tablet 200 mg
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Simplovir Tablet 200 mg
Generic	Acyclovir (Oral)
Weight	200 mg
Type	Tablet
Therapeutic Class	Herpes simplex & Varicella-zoster virus infections
Manufacturer	Incepta Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Aciclovir is indicated for- The treatment of viral infections due to Herpes simplex virus (type I & II) and Varicella zoster virus (herpes zoster & chicken pox). The treatment of Herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes and herpes labialis. The prophylaxis of Herpes simplex infections in immunocompromised patients

Dosage

Simplovir Tablet 200 mg dosage

Treatment of initial herpes simplex: 200 mg 5 times daily usually for 5 days. For immunocompromised patients: Adult: 400 mg 5 times daily for 5 days (longer if new lesions appear during treatment or if healing is incomplete; increase dose to 800 mg 5 times daily for genital herpes in immunocompromised) or as directed by the registered physician. Children under 2 years: Half of the adult dose. Children over 2 years: Adult dose. Prevention of recurrence of herpes simplex: Adult: 200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months. Children under 2 years: Half of the adult dose. Children over 2 years: Adult dose. Prophylactic treatment of herpes simplex in the immunocompromised patients: Adult: 200 to 400 mg 4 times daily. Children under 2 years: Half of the adult dose. Children over 2 years: Adult dose. Treatment of vericella (chicken pox): Adult and children over 40 kg: 800 mg 4 times daily for 5 days. Children below 40 kg: 20 mg/kg (maximum 800 mg) per dose orally 4 times daily (80 mg/kg/day) for 5 days. Children 1 month-2 years: 200 mg 4 times daily for 5 days. Children 2-5 years:400 mg 4 times daily for 5 days. Children 6-12 years:800 mg 4 times daily for 5 days. Treatment of herpes zoster (Shingles): 800 mg 5 times daily for 7 days.Treatment of initial rectal (Proctitis) herpes infections: An oral Aciclovir dosage of 400 mg 5 times daily for 10 days or until clinical resolution occurs has been recommended.Renal Impairment: For patients with severe renal impairment, a reduction of the doses is recommended.

Side Effects

Rash, gastrointestinal disturbance, rise in bilirubin and liver-related enzymes, increase in blood urea and creatinine, decrease in hematological indices, headache, neurological reaction, fatigue.

Precaution

Aciclovir should be administered with caution in patients with renal impairment and doses should be adjusted according to creatinine clearance. Monitor neutrophil count at least twice weekly in neonates.

Interaction

Probenecid reduces Aciclovir excretion and so increases plasma concentration and risk of toxicity.

Pregnancy & Breastfeeding use

Pregnancy category B. Aciclovir should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. Caution should be exercised when it is administered to a nursing mother.