Sinarzine
Sinarzine Uses, Dosage, Side Effects, Food Interaction and all others data.
Sinarzine provides quick relief of various symptoms of cerebral and peripheral circulation disorders. Sinarzine protects attacks of vascular headache such as migraine. Sinarzine normalizes cerebral circulation time and improves cerebral irrigation in patients suffering from the disorders of cerebral circulation. Sinarzine normalizes arterial pulsations in patients suffering from vasospastic disorders. Sinarzine significantly increases the rate of inflow or pulsation and the blood flow in the most affected limb as well as the walking distance of patients suffering from intermittent claudication.
Sinarzine acts as an antihistamine, labyrinthine sedative and a peripheral antivasoconstrictor. Inarzin is a selective calcium antagonist, inhibiting the influx of Ca2+ intracellularly. It prevents the Ca2+ dependent contraction of arterial smooth muscle by inhibiting Ca2+ influx through smooth muscle calcium channels and thereby, improves vestibular symptoms and prevents peripheral arterial disease.
Sinarzine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Sinarzine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Sinarzine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
| Trade Name | Sinarzine |
| Generic | Cinnarizine |
| Cinnarizine Other Names | Cinarizina, Cinnarizine, Cinnarizinum |
| Type | Tablet |
| Formula | C26H28N2 |
| Weight | Average: 368.524 Monoisotopic: 368.22524891 |
| Groups | Approved, Investigational |
| Therapeutic Class | Anti vertigo drugs |
| Manufacturer | Leeford Healthcare Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
It is mainly used for the symptomatic treatment of nausea and vertigo due to Meniere's disease and other labyrinthine disturbances and for the prevention and treatment of motion sickness. It is also used in the management of various vascular disorders.
Cerebral circulatory disorders:
- Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis such as dizziness, ear buzzing (tinnitus), vascular headache, unsociability and irritability, fatigue, sleep rhythm disorders such as premature awakening, involutional depressions, loss of memory and lack of concentration, incontinence and other disorders due to aging.
- Sequel of cerebral and cranial trauma.
- Post-apoplectic disorders.
- Migraine.
Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis, thromboangitis obliterans, Raynaud's disease, diabetes, acrocyanosis, perrio, etc.) such as: intermittent claudication, trophic disturbances, pregangrene, trophic and varicose ulcers, paraesthesia, nocturnal cramps, cold extremities.
Disorders of balance:
- Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis, vestibular irritability, Meniere's syndrome, such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting.
- Prophylaxis of motion sickness.
Sinarzine is also used to associated treatment for these conditions: Balance Disorders, Dizziness, Motion Sickness, Nausea, Peripheral Artery Disease (PAD), Raynaud's Phenomenon, Inadequate cerebral circulation, Peripheral vasculopathy
How Sinarzine works
Sinarzine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Sinarzine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.
Dosage
Sinarzine dosage
Peripheral vascular disease:
- Adult: 75 mg bid or tid.
Cerebrovascular disorders:
- Adult: 75 mg once daily.
Motion sickness:
- Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary.
- Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary.
Vertigo and vestibular disorders:
- Adult: 30 mg tid or 75 mg 1-2 times daily.
- Child: 5-12 yr 15 mg tid.
Side Effects
Side effects such as somnolence and gastrointestinal disturbances are extremely rare. They are transient and may be readily prevented by achieving the optimal dosage gradually. Combination therapy with other drugs is possible. Whenever indicated, caution should be taken in hypotension (high doses). Rarely, extrapyramidal symptoms in elderly on prolonged therapy.
Precaution
Patient with hypotension (high dose), Parkinson's disease, porphyria. Renal and hepatic impairment. Childn. Pregnancy and lactation.
Interaction
Concurrent use of alcohol, CNS depressants or tricyclic antidepressants may potentiate the sedative effects of either these drugs or of Sinarzine. Therefore, it is advisable to avoid these drugs while taking Sinarzine.
Pregnancy & Breastfeeding use
Pregnancy Category C. The safety of Sinarzine in human pregnancy has not been established. Therefore, it is not advisable to administer Sinarzine in pregnancy.
Lactation: It is not known if Sinarzine is excreted in human breast milk. Use of Sinarzine during breast feeding is not advised.
Contraindication
Contraindicated in Known hypersensitivity to Sinarzine, Parkinson’s disease, Hypotension
Special Warning
Neonates: Sinarzine is not indicated in neonates.
Acute Overdose
Symptoms: Consciousness alterations ranging from somnolence to stupor and coma, vomiting, extrapyramidal symptoms, hypotonia; seizures may occur in young children.
Management: Symptomatic and supportive treatment. May consider admin of activated charcoal within 1 hr of ingestion.
Innovators Monograph
You find simplified version here Sinarzine
Sinarzine contains Cinnarizine see full prescribing information from innovator Sinarzine Monograph, Sinarzine MSDS, Sinarzine FDA label
FAQ
What is Sinarzine used for?
It's used for travel sickness (also called motion sickness) dizziness and sickness caused by inner ear problems (such as vertigo, tinnitus and Ménière's disease).
How safe is Sinarzine?
Sinarzine can safe to be taken by most adults and children aged 5 years and above. Sinarzine is not suitable for some people. Tell your doctor or pharmacist if you have: had an allergic reaction to Sinarzine or any other medicines in the past.
How does Sinarzine work?
Sinarzine blocks the receptors in the vomiting centre, preventing it from receiving nerve messages from the vestibular apparatus. This helps to reduce symptoms such as nausea, vomiting dizziness and vertigo.
What are the common side effects of Sinarzine?
Common side effects of include are drowsiness, sweating, dry mouth, headache, skin problems, lethargy, gastrointestinal irritation, hypersensitivity reactions, as well as movement problems/muscle rigidity, and tremor.
Is Sinarzine safe during pregnancy?
Sinarzine is not usually recommended during pregnancy.
Is Sinarzine safe during breastfeeding?
Sinarzine is not usually recommended during pregnancy or while breastfeeding.
Can I drink alcohol with Sinarzine?
Avoid drinking alcohol while taking Sinarzine. Alcohol increases the chance of side effects. To prevent travel sickness, take Sinarzine 2 hours before your journey. You can take another dose 8 hours later if you need to.
Can I drive after taking Sinarzine?
Sinarzine can cause drowsiness. If this happens, do not drive and do not use tools or machines.
When should be taken of Sinarzine?
To prevent travel sickness, take Sinarzine 2 hours before your journey. You can take another dose 8 hours later if you need to.
Can Sinarzine be taken without food?
Sinarzine should preferably be taken after meals. The tablets may be sucked, chewed or swallowed whole with water.
How long does Sinarzine take to work?
Sinarzine can take up to 4 hours for the medicine to reach its full effect.
What is the half-life of Sinarzine?
The reported elimination half-life for Sinarzine ranges from 4 to 24 hours.
Who should not take Sinarzine?
Contraindicated in patients with Parkinson's disease, newborns, and hypersensitivity.
What happen If I stop taking Sinarzine?
If you've been prescribed Sinarzine to help with inner ear problems, your symptoms may return if you stop taking it.
What happens if I miss a dose?
If you forget to take a dose of Sinarzine, take it as soon as you remember. Unless it's nearly time for your next dose. In which case, skip the missed dose and take your next dose at the usual time. It's important to leave at least 8 hours between doses. Do not take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.
What happen if I overdose on Sinarzine?
Taking too much Sinarzine can make you very sleepy or confused, feel sick or be sick, feel weak or shaky, or give you a very fast, uneven or pounding heartbeat (palpitations). Too much Sinarzine can give a child a fit or seizure.
Can Sinarzine causes my weight gain?
Sinarzine may cause weight gain.
Can Sinarzine cause heart palpitations?
Taking too much Sinarzine can make you very sleepy or confused, feel sick or be sick, feel weak or shaky, or give you a very fast, uneven or pounding heartbeat .
Can Sinarzine be taken long term?
Sinarzine should not be taken long term due to its potential side effects. Limiting pack size may reduce the likelihood of long term use.
Can I take Sinarzine every day?
Adults and children aged 12 years or older – the usual dose is 2 tablets, taken 3 times a day. Children aged 5 to 11 years – the usual dose is 1 tablet, taken 3 times a day.
