Sintonal

Sintonal Uses, Dosage, Side Effects, Food Interaction and all others data.

Sintonal is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Sintonal has similar effects to short-acting benzodiazepines such as triazolam. Sintonal is indicated for 2-4 weeks of treatment for severe or debilitating insomnia. Sintonal is an extremely potent drug and it is rapidly eliminated with an average half-life of 4.4 hours (range 3.6 - 7.9 hours).

Sintonal is not approved for sale in the UK, United States or Canada but is sold in the Netherlands, Germany, Spain, Belgium, Austria, Portugal, Israel, Italy and Japan.

Table Of contents

• Sintonal
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Sintonal
Generic	Brotizolam
Brotizolam Other Names	Brotizolam, Brotizolamum
Type
Formula	C15H10BrClN4S
Weight	Average: 393.689 Monoisotopic: 391.949807384
Protein binding	The mean value of the free fraction (%): 8.4 ± 0.7.
Groups	Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Sintonal is a benzodiazepine analogue with sedative-hypnotic properties used for short-term treatment of severe or debilitating insomnia.

Sintonal is indicated for 2-4 weeks in the treatment of severe or debilitating insomnia.

Sintonal is also used to associated treatment for these conditions: Insomnia

Volume of Distribution

0.63 l/kg.

Elimination Route

The plasma concentration profile of brotizolam can be described as a one compartmental open model with first-order absorption.

Half Life

4.4 hours.

Clearance

Total clearance: 109 ml/min.

Innovators Monograph

You find simplified version here Sintonal