Sinuva
Sinuva Uses, Dosage, Side Effects, Food Interaction and all others data.
Sinuva is a corticosteroid demonstrating anti-inflammatory properties. The precise mechanism of corticosteroids action on allergic rhinitis is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.
Sinuva is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. When glucocorticoids are discontinued, asthma stability may persist for several days or longer. Sinuva has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone. The clinical significance of these findings is unknown.
| Trade Name | Sinuva |
| Availability | Prescription only |
| Generic | Mometasone |
| Mometasone Other Names | Mometason, Mometasona, Mométasone, Mometasone, Mometasonum |
| Related Drugs | Dupixent, Xolair, ProAir Digihaler, Symbicort, Breo Ellipta, Ventolin, Xopenex, Ventolin HFA |
| Weight | 1350mcg, 370mcg, 50mcg/inh, |
| Type | Nasal implant, nasal spray |
| Formula | C22H28Cl2O4 |
| Weight | Average: 427.361 Monoisotopic: 426.136464798 |
| Protein binding | 98% to 99% (in a concentration range of 5 to 500 ng/mL). |
| Groups | Experimental |
| Therapeutic Class | Other Topical corticosteroids |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sinuva cream is used for the relief of inflammatory and pruritic manifestations of corticosteroid- responsive dermatoses, such as psoriasis and atopic dermatitis.
Sinuva is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Bacterial Sinusitis, Dermatitis, Pruritus, Sinusitis
How Sinuva works
Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Sinuva furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone.
Dosage
Sinuva dosage
A thin film of Sinuva Furoate cream should be applied to the affected skin areas once daily.Safety and effectiveness in paediatric patients below 2 years of age have not been established.
Side Effects
Sinuva Furoate cream is generally well tolerated. Burning, Pruritus and skin atrophy may occur.
Toxicity
The potential for acute toxic effects following overdose with the mometasone inhaler is low. However, habitual overuse of the product can cause symptoms of steroid overload, including menstrual irregularities, acne, obesity, and muscle weakness. Single oral doses up to 8000 µg have been studied on human volunteers with no adverse events reported.
Precaution
If irritation develops with the use of Sinuva Furoate cream, treatment should be discontinued.
Food Interaction
No interactions found.Sinuva Drug Interaction
Minor: fluticasone / salmeterol, albuterol, budesonide / formoterolUnknown: aspirin, diphenhydramine, duloxetine, omega-3 polyunsaturated fatty acids, furosemide, pregabalin, metoprolol, polyethylene glycol 3350, esomeprazole, montelukast, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, ranitidine, cetirizine
Sinuva Disease Interaction
Elimination Route
Nasal spray is virtually undetectable in plasma
Half Life
5.8 hours
Pregnancy & Breastfeeding use
Pregnancy: There is no adequate and well-controlled studies in pregnant women.
Lactation: It is not known whether this drug passes into breast milk.
Contraindication
The drug is contraindicated in individuals with a history of sensitivity reactions to Sinuva or any of the components of the preparation.
Innovators Monograph
You find simplified version here Sinuva
Sinuva contains Mometasone see full prescribing information from innovator Sinuva Monograph, Sinuva MSDS, Sinuva FDA label
