Siofin
Siofin Uses, Dosage, Side Effects, Food Interaction and all others data.
Fusidic acid is an antimicrobial agent that inhibits bacterial protein synthesis. Fusidic acid interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Fusidic acid is active against a wide range of gram-positive organisms. The sustained release formulation ensures prolonged contact with the conjunctival sac. Fusidic acid penetrates well into the aqueous humor.
Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.
| Trade Name | Siofin |
| Generic | Fusidic Acid |
| Fusidic Acid Other Names | Acide fusidique, Acido fusidico, Acidum fusidicum, Fucidate, Fucidin acid, Fusidate, Fusidic acid, Fusidine, Ramycin |
| Type | Ointment, Cream |
| Formula | C31H48O6 |
| Weight | Average: 516.7092 Monoisotopic: 516.345089268 |
| Protein binding | 97 to 99% |
| Groups | Approved, Investigational |
| Therapeutic Class | Miscellaneous Antibiotics |
| Manufacturer | Albert David Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Siofin is used for the topical treatment of superficial bacterial infections of the eye and its adnexa. These may include - bacterial conjunctivitis, blepharoconjunctivitis, blepharitis, sty and keratitis. It may also be used for the management of corneal and conjunctival abrasions and foreign body injuries.
Siofin is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Eye and eyelid infections, Fungal skin infection, Skin Infections caused by Corynebacterium minutissimum infection, Skin Infections caused by Staphylococcus Aureus, Skin Infections caused by Streptococcus Infection, Skin Infections, Bacterial, Stye, Cutaneous dermatophyte infection, Eczematous rash, Mild Atopic dermatitis, Mild Dermatitis caused by Staphylococcus aureusis, Moderate Atopic dermatitis, Moderate Dermatitis caused by Staphylococcus aureusis, Ocular bacterial infections, Susceptible Bacterial Infections
How Siofin works
Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Dosage
Siofin dosage
Adults and children (≥ 2 years): Instill one drop in the affected eye(s) twice daily for 7 days. Treatment should be continued for at least 48 hours after the eye returns to normal.
Side Effects
Fusidic acid is generally associated with very few adverse effects. The most frequently reported treatment-related side-effect is slight stinging or irritation.
Precaution
- For ophthalmic use only
- To avoid possible contamination of the drops, do not touch the tube nozzle or to any surface
- Do not wear contact lenses during the treatment
- If more than one topical eye drug is being used, the drugs should be administered at least five (5) minutes interval between applications
Interaction
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Food Interaction
- Take with food. Food reduces irritation.
Elimination Route
Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Half Life
Approximately 5 to 6 hours in adults.
Pregnancy & Breastfeeding use
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Fusidic acid should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Use in lactation: It is not clear if enough medication from the eye drop would pass into breast milk. Caution should be exercised while giving this eye drops to a nursing mother
Contraindication
Fusidic acid viscous eye drops is contraindicated in patients who are hypersensitive to any component of Siofin (Eye Drops).
Special Warning
Use in children: Safety & effectiveness in children below the age of 2 years have not been established.
Storage Condition
Store between 2-25°C. Discard 1 mth after opening.
Innovators Monograph
You find simplified version here Siofin
FAQ
What is Siofin used for?
Siofin is an antibiotic that is often used topically in creams and eyedrops but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently. Siofin cream should be used on the skin. The cream is used for the local treatment of skin infections caused by bacteria that are sensitive to Siofin such as impetigo (a weeping, crusty and swollen patch of skin), folliculitis, sycosis barbae, paronychia, erythrasma.
How safe is Siofin?
There is inadequate evidence of safety in human pregnancy. Animal studies and many years of clinical experience suggest that Siofin is devoid of teratogenic effects (birth defects), but Siofin can cross the placental barrier.
How does Siofin work?
Siofin works by stopping the growth of the germs causing the infection.
What are the common side effects of Siofin?
Common side effects of Siofin are include:
- Skin rashes.
- Skin itching.
- Pain, stinging, burning sensation or redness of skin on application.
- Contact dermatitis.
Is Siofin safe during pregnancy?
It's safe to use Siofin cream, ointment or eye drops while you're pregnant. Very little of the medicine gets to your baby, and the small amount that does will not harm them.
Is Siofin safe during breastfeeding?
Siofin cream can be used during breastfeeding but it is recommended to avoid applying Siofin cream on the breast.
Is Siofin cream safe for babies?
Using Siofin cream topically and breast-feeding is unlikely to harm your baby.
Can I use Siofin daily?
Apply a small amount to the affected area 2 to 3 times daily for 7 to 14 days. If your doctor has directed you to cover the lesion with a gauze dressing, you may be directed to apply the medication only 1 or 2 times daily.
How long does Siofin stay in my system?
The usual treatment time is up to 2 weeks. You should notice your skin improve after just a few days of using the cream. If there is no improvement after 7 days you should stop using the cream and go back to your doctor.
Is Siofin good for acne?
Topical Siofin is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Siofin is often partially effective at improving acne symptoms.
How often can I use Siofin ?
It's usual to put on Siofin cream or ointment 3 or 4 times a day.
What happens if I miss a dose of Siofin?
If you forget to apply this Siofin, apply it as soon as you remember. If it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Who should not take Siofin?
Siofin topical products should not be used If you have allergic to Siofin and its salts or to any of the ingredients of this medication.
When can I stop using Siofin ?
Treatment should be stopped after 7 days if your skin has not improved after using Siofin cream.
What happen if I take too much Siofin?
If you apply too much Siofin cream, it is unlikely to cause any harm. However, if you notice any effect or are worried, contact your doctor or pharmacist.
Is Siofin a strong antibiotic?
Siofin is a steroidal antibiotic and the only marketed member of the fusidane class.
Is Siofin an antifungal?
Siofin showed that compound 7 had strongest antifungal activity.
Is Siofin good for pimples?
Topical Siofin is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Siofin is often partially effective at improving pimples.
Can Siofin be used for cold sores?
No, Siofin is inapplicable on cold sores.
Is Siofin cream good for cuts?
Siofin is made to be put directly on skin and wounds.
