Sodium Nitrite And Sodium Thiosulfate

Sodium Nitrite And Sodium Thiosulfate Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.

Table Of contents

• Sodium Nitrite And Sodium Thiosulfate
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Sodium Nitrite And Sodium Thiosulfate
Generic	Sodium nitrite + sodium thiosulfate
Weight	30mg + 250mg/ml,
Type	Intravenous Solution, Intravenous
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cyanide poisoning

Dosage

Sodium Nitrite And Sodium Thiosulfate dosage

Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

Side Effects

Osmotic disturbances. Oral: catharsis (at high doses).

Precaution

May irritate eyes, skin and respiratory tract.

Interaction

Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.

Pregnancy & Breastfeeding use

Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Oedematous sodium-retaining conditions.

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