Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide

Uses

This eye drops is used for the treatment of lens opacification.

Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide is also used to associated treatment for these conditions: Paroxysmal Supraventricular Tachycardia, SVT, Tachycardia, Supraventricular, Symptomatic pulmonary arterial hypertension (PAH)Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation

How Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide works

Agonism of adenosine receptors A1 and A2 reduces conduction time in the atrioventricular node of the heart. Conduction time is decreased by inducing potassium efflux and inhibiting calcium influx through channels in nerve cells, leading to hyperpolarization and and increased threshold for calcium dependent action potentials. Decreased conduction time leads to an antiarrhythmic effect. Inhibition of calcium influx, reduces the activity of adenylate cyclase, relaxing vascular smooth muscle. Relaxed vascular smooth muscle leads to increased blood flow through normal coronary arteries but not stenotic arteries, allowing thallium-201 to be more readily uptaken in normal coronary arteries.

Dosage

Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide dosage

One drop into the affected eye twice daily.

Side Effects

Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide may cause more or less discomfort in some patients like any other drug. If any discomfort occurs, it is recommended to consult doctor.

Toxicity

Patients experiencing an overdose of adenosine may present with asystole, heart block, or cardiac ischemia; though the effects are generally short lived. Patients experiencing an overdose should be treated with symptomatic and supportive care, which may include a slow intravenous injection of theophylline.

The LD₅₀ in mice is >20 g/kg subcutaneously, 500mg/kg intraperitoneally, and 39.6 µg/kg subcutaneously.[L32048]

Precaution

Only for topical ophthalmic use. Do not inject or swallow. In case of concomitant treatment with another ophthalmic solution, wait 15 minutes between each instillation.

Interaction

To avoid interaction with other drugs, it is recommended to inform your doctor of any concomitant treatment particularly with other eye drops.

Volume of Distribution

Data regarding the volume of distribution of adenosine are not readily available.

Elimination Route

Data regarding the absorption of adenosine are not readily available.

Half Life

The half life of adenosine in blood is less than 10 seconds.

Clearance

Data regarding the clearance of adenosine are not readily available.

Elimination Route

Adenosine is predominantly eliminated in the urine as uric acid.

Pregnancy & Breastfeeding use

In pregnancy and lactation, it is recommended to take advice from doctor before using Sodium Succinate + Cytochrome C + Adenosine + Nicotinamide eye drops.

Contraindication

This eye drops is contraindicated in patients with known hypersensitivity to any ingredient of the product.

Acute Overdose

Generally it does not cause any toxicity even after accidental ingestion of the medicine due to low quantity of ingredients.

Interaction with other Medicine

No specific drug interaction has been demonstrated.

Storage Condition

Store in a cool, dry place & protected from light

Keep out of reach of children

Do not use more than 4 weeks after opening

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