Sodium Thiosulfate-Darnitsa

Sodium Thiosulfate-Darnitsa Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium thiosulfate acts as an antidote in the treatment of cyanide poisoning. It acts as a sulphur-donating substrate for the enzyme rhodanese, thus speeding up the conversion of cyanide to thiocyanide, which is relatively non toxic. It is often used in combination with sodium nitrite but may be used alone in less severe poisoning.

Sodium Thiosulfate-Darnitsa
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Sodium Thiosulfate-Darnitsa
Generic	Sodium Thiosulfate
Type
Therapeutic Class	Antidote preparations
Manufacturer
Available Country	Georgia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cyanide poisoning

Dosage

Sodium Thiosulfate-Darnitsa dosage

Adult: To be given after 300 mg of sodium nitrite has been admin over 5-20 min: 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution) given over 10 min. Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

Child: To be given after 4-10 mg/kg of sodium nitrite (max: 300 mg) has been admin: 400 mg/kg of sodium thiosulfate, as a 25 or 50% solution (max: 12.5 g). Methaemoglobin concentration should not exceed 30-40%. If symptoms of cyanide toxicity recur, the doses of nitrite and thiosulfate may be repeated after 30 min at half the initial doses.

Side Effects

Osmotic disturbances. Oral: catharsis (at high doses).

Precaution

May irritate eyes, skin and respiratory tract.

Interaction

Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.

Pregnancy & Breastfeeding use

Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Oedematous sodium-retaining conditions.

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FAQ

What is Sodium Thiosulfate-Darnitsa used for?

Sodium Thiosulfate-Darnitsa used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.

How safe is Sodium Thiosulfate-Darnitsa?

Ingestion of large amounts may cause gastrointestinal irritation.May cause respiratory tract irritation. Low hazard for usual industrial handling.

How does Sodium Thiosulfate-Darnitsa work?

Sodium Thiosulfate-Darnitsa works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

What are the common side effects of Sodium Thiosulfate-Darnitsa?

Common side effects of Sodium Thiosulfate-Darnitsa are include:

Agitation.
hallucinations (seeing, hearing, or feeling things that are not there)
mental changes.
muscle cramps.
nausea and vomiting.
pain in the joints.
ringing in the ears.

Is Sodium Thiosulfate-Darnitsa safe during pregnancy?

If Sodium Thiosulfate-Darnitsa is required in the management of cyanide poisoning during pregnancy, treatment should not be withheld on account of pregnancy.

Is Sodium Thiosulfate-Darnitsa safe during breastfeeding?

Breastfeeding is not recommended.There is no information regarding this drug on the presence in human milk, the effects on a breastfed infant, or effects on milk production.

What happens if I ingest Sodium Thiosulfate-Darnitsa?

light-headed feeling, like you might pass out, shortness of breath, tiredness; fast or irregular heart rate, pounding heartbeats or fluttering in your chest.

What does Sodium Thiosulfate-Darnitsa do to the body?

Sodium Thiosulfate-Darnitsa works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

How quickly does Sodium Thiosulfate-Darnitsa work?

Symptomatic relief and clinical improvement may occur within 2 weeks.

Is Sodium Thiosulfate-Darnitsa good for skin?

Sodium Thiosulfate-Darnitsa is used to treat a fungal infection of the skin called tinea versicolor.

Is Sodium Thiosulfate-Darnitsa bad for my skin?

Do not put on irritated skin. If you use Sodium Thiosulfate-Darnitsa and salicylic acid too often, your skin problem may become worse. Talk with your doctor before you use other drugs or products on your skin.

Does Sodium Thiosulfate-Darnitsa lower blood pressure?

Sodium Thiosulfate-Darnitsa can causes Low blood pressure also with other side effects.

When do I administer Sodium Thiosulfate-Darnitsa?

Sodium Thiosulfate-Darnitsa may be administered soon after prior treatment with a fast-acting cyanide antidote such as Sodium Thiosulfate-Darnitsa. Blood pressure must be monitored during infusion in both adults and children. The rate of infusion should be decreased if significant hypotension is noted.

Is Sodium Thiosulfate-Darnitsa light sensitive?

None under normal processing. Chemical Stable under normal conditions. Light sensitive.

Is Sodium Thiosulfate-Darnitsa a salicylic acid?

Sodium Thiosulfate-Darnitsa is an antifungal medicine that fights infections caused by fungus. salicylic acid helps your skin absorb the sodium thiosulfate.

Is Sodium Thiosulfate-Darnitsa a chemical antidote?

Sodium Thiosulfate-Darnitsa can be used for treatment of acute cyanide poisoning in combination with sodium nitrite.

How long is Sodium Thiosulfate-Darnitsa good for?

At the time of the case report, 18 months had elapsed since the infusions were discontinued, and the patient remained free of skin lesions. Based on the lack of recurrence with extended treatment, the authors suggested that the optimal duration of Sodium Thiosulfate-Darnitsa therapy is several months.

Is Sodium Thiosulfate-Darnitsa harmful to fish?

Excess Sodium Thiosulfate-Darnitsa up to 100 parts per million will not harm fish.

How quickly does Sodium Thiosulfate-Darnitsa work?

Symptomatic relief and clinical improvement may occur within 2 weeks.

Does Sodium Thiosulfate-Darnitsa remove oxygen?

Sodium Thiosulfate-Darnitsa acts as an oxygen scavenger. Oxygen scavengers are reducing agents in that they remove dissolved oxygen from water by reducing molecular oxygen to compounds in which oxygen appears in the lower.

Can I overdose Sodium Thiosulfate-Darnitsa?

Sodium Thiosulfate-Darnitsa is used to treat cyanide poisoning. If a poisoning or overdose occurs, get emergency help. Do not treat a poisoning or overdose yourself.