Soframycin
Soframycin Uses, Dosage, Side Effects, Food Interaction and all others data.
Soframycin is an aminoglyoside antibiotic which is the major component of neomycin. Susceptible organisms include many gram-negative bacteria (but not Pseudomonas) and many strains of Staphylococcus. Used topically in the treatment of skin, eye and ear infections often in combination with steroids and other antimicrobials.
Soframycin is used for the treatment of bacterial eye infections such as conjunctivitis. Soframycin is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Soframycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Soframycin is useful primarily in infections involving aerobic bacteria bacteria.
| Trade Name | Soframycin |
| Generic | Framycetin |
| Framycetin Other Names | Fradiomycin B, Framicetina, Framycetin, Framycétine, Framycetinum, Neomycin B |
| Type | Powder, Eye Drops, Skin Cream |
| Formula | C23H46N6O13 |
| Weight | Average: 614.6437 Monoisotopic: 614.312285588 |
| Groups | Approved |
| Therapeutic Class | Dressing products for wounds/burns/ulcers, Ophthalmic antibacterial drugs |
| Manufacturer | Sanofi |
| Available Country | India, Australia, Switzerland, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Abrasion, Bites, Blepharitis, Conjunctivitis, Conjunctivitis, blepharitis and blepharoconjunctivitis, Dermatitis, Eye infections, Lactation, Ocular infections, Posttraumatic or pre- and postoperative otitis externa, Skin infections, Wounds
Soframycin is also used to associated treatment for these conditions: Acute Crusting Rhinitis, Conjunctivitis, Corneal Abrasions, Infection, Skin Infections, Bacterial, Stye, Ulcerative keratitis, Acute rhino-sinusitis, Bacterial blepharitis, Nasal carriage of staphylococci
How Soframycin works
Soframycin binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Dosage
Soframycin dosage
Ophthalmic-
Conjunctivitis, blepharitis and blepharoconjunctivitis: As 0.5% ointment. Apply 2-3 times daily into the affected eyes.Otic/Aural-
Posttraumatic or pre- and postoperative otitis externa: As 0.5% drops: Use as directed.Topical/Cutaneous-
Skin infections: As sulfate: Apply 1% dressing onto affected area.
Side Effects
Ototoxicity, if large areas used in high-risk groups; sensitisation, contact dermatitis, local irritation and itching.
Precaution
If large areas of skin are being treated, ototoxicity may be a hazard, particularly in children, elderly and those with renal impairment. Pregnancy.
Interaction
Co-admin of gramicidin with framycetin reduces the risk of selecting resistant bacteria.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy category-C
Contraindication
Hypersensitivity, perforated ear drums (ear drops), fungal/viral or resistant bacterial eye infections (eye drops with steroids).
Innovators Monograph
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