Solastay S1

Solastay S1 Uses, Dosage, Side Effects, Food Interaction and all others data.

Solastay S1 is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various lotions, creams, sprays, sticks, and gel formulations . It currently enjoys regional approvals in Canada, the EU, and the US .

As an active ingredient in topical sunscreen products, ethylhexyl methoxycrylene is applied directly onto human skin where it acts as a critical component for conferring photostability to the product's other constituent ingredients, protecting the product as a whole from deterioration in the sunlight . Additionally, considering the high log Pow value (6.05-6.32) and low water solubility, dermal absorption of ethylhexyl methoxycrylene is expected to be low. This is supported by a dermal absorption of less than 5% observed for an acceptable analogue of the notified chemical . Consequently, little systemic exposure and pharmacokinetics are expected and users can freely wash off and re-apply ethylhexyl methoxycrylene containing compounds as necessary.

Trade Name Solastay S1
Generic Ethylhexyl methoxycrylene
Type
Formula C25H29NO3
Weight Average: 391.511
Monoisotopic: 391.214743798
Protein binding

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.

Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Solastay S1
Solastay S1

Uses

Solastay S1 is employed as a photostabilizing agent in various sunscreen products .

Solastay S1 is also used to associated treatment for these conditions: Sunburn

How Solastay S1 works

Solastay S1 is a photostabilizer with exceptionally low singlet (S1) and triplet (T1) energy states . Given these properties, ethylhexyl methoxycrylene is capable of draining the singlet excited state reservoir of UV radiation excited molecules of various sunscreen agents . This action used to be considered impossible because molecules stay in the singlet excited state for a very short period of time - often as short as 13 one-thousandths of a billionth of a second . Solastay S1, however, is a singlet quencher that dramatically reduces the flow of energy to the triplet escited state reservoir . As it quenches the singlet excited state, molecules do not have the chance to get to the triplet excited state reservoir and largely return to the ground state where they can continue functioning . In fact, this mechanism of action of ethylhexyl methoxycrylene is considered as being able to return UV filters to their ground states without absorbing sunlight .

Ultimately, because ethylhexyl methoxycrylene can work so quickly, it allows manufacturers to formulate products with combinations of sunscreen ingredients that used to be considered too photo-unstable to be effective . Moreover, ethylhexyl methoxycrylene is easily emulsified, and is suitable for use in lotions, creams, sprays, sticks, and gel formulations .

Toxicity

Solastay S1 is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. Additionally, no ocular irritation, phototoxicity, dermal irritation, or allergic contact sensitization has been reported to any significant degree .

Food Interaction

No interactions found.

Volume of Distribution

Solastay S1 is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.

Elimination Route

Solastay S1 is reported as having little to no absorption through the skin . At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited . Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use .

Half Life

Solastay S1 is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.

Clearance

Solastay S1 is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.

Elimination Route

Solastay S1 is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.

Innovators Monograph

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