SOMAVERT15mgpóesolventeparasoluçãoinjectável
SOMAVERT15mgpóesolventeparasoluçãoinjectável Uses, Dosage, Side Effects, Food Interaction and all others data.
SOMAVERT15mgpóesolventeparasoluçãoinjectável is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Somavert is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.
Trade Name | SOMAVERT15mgpóesolventeparasoluçãoinjectável |
Availability | Prescription only |
Generic | Pegvisomant |
Pegvisomant Other Names | Pegvisomant |
Related Drugs | octreotide, bromocriptine, Sandostatin, lanreotide, Somatuline Depot, Parlodel |
Type | |
Formula | C990H1532N262O300S7 |
Weight | 22129.0 Da |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | Portugal |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
SOMAVERT15mgpóesolventeparasoluçãoinjectável is a growth hormone receptor antagonist used to treat acromegaly.
SOMAVERT15mgpóesolventeparasoluçãoinjectável is a growth hormone receptor antagonist used for the treatment of acromegaly.
SOMAVERT15mgpóesolventeparasoluçãoinjectável is also used to associated treatment for these conditions: Acromegaly
How SOMAVERT15mgpóesolventeparasoluçãoinjectável works
Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
Food Interaction
No interactions found.SOMAVERT15mgpóesolventeparasoluçãoinjectável Drug Interaction
Unknown: charcoal, apomorphine, timolol, sulfamethoxazole / trimethoprim, ubiquinone, entacapone, copper gluconate, glucose, diltiazem, diltiazem, carbidopa / levodopa, sacubitril / valsartan, lamivudine, pirfenidone, anti-inhibitor coagulant complex, antihemophilic factor, givosiran, glycerin, heparin, acetaminophen
SOMAVERT15mgpóesolventeparasoluçãoinjectável Disease Interaction
Volume of Distribution
- 7 L
Half Life
~6 days
Clearance
- 36 - 28 mL/h [SC doses ranging from 10 to 20 mg/day]
Innovators Monograph
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