Spaglumic acid

Spaglumic acid Uses, Dosage, Side Effects, Food Interaction and all others data.

Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis.

Spaglumic acid
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Precautions
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Spaglumic acid
Generic	Spaglumic acid
Spaglumic acid Other Names	Spaglumic acid
Type
Formula	C₁₁H₁₆N₂O₈
Weight	Average: 304.255 Monoisotopic: 304.090665483
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate, a naturally occurring neurotransmitter, used in allergic eye conditions due to its ability to stabilize mast cells.

Used in patients with allergic conjunctivitis.

Spaglumic acid is also used to associated treatment for these conditions: Ocular Inflammation

How Spaglumic acid works

Spaglumic acid is a mast cell stabilizer. Mast cells are involved in producing an allergic response by releasing inflammatory mediators such as histamine. Mast cell stablizers block the release of histamine and other mediators by inhibiting mast cell degranulation, which is the process of releasing these mediators. Inhibition occurs through inhibition of specific calcium channels to stabilize the mast cell and prevent degranulation.