Spasmaverine

Spasmaverine Uses, Dosage, Side Effects, Food Interaction and all others data.

Spasmaverine Citrate is an anti-spasmodic medicine. It relaxes the muscles in the intestine (gut) and uterus (womb). This helps to stop the pain when the muscles become tense.

Spasmaverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Spasmaverine acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as heartburn, abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Spasmaverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).

Spasmaverine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Spasmaverine
Generic	Alverine
Alverine Other Names	Alverina, Alverine, Alverinum, Phenopropamine, Phenpropamine
Type
Formula	C₂₀H₂₇N
Weight	Average: 281.4351 Monoisotopic: 281.214349869
Groups	Approved, Investigational
Therapeutic Class	Anticholinergics
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Spasmaverine Citrate is used for Irritable Bowel Syndrome (IBS), also can be used for a condition of the large intestine called painful diverticular disease of the colon and to relieve period pains.

Spasmaverine is also used to associated treatment for these conditions: Abdominal Pain

Dosage

Spasmaverine dosage

The usual dose is 60-120 mg 3 times a day.

Side Effects

Yellowing of the whites of the eyes and the skin, as inflammation of the liver has been known to occur. Difficulties in breathing, shortness of breath, wheezing, swelling of face or other parts of body. A feeling of sickness or dizziness. Headache. Allergic reactions, which may include itching or skin rash.

Toxicity

Can produce hypotension and atropine-like toxic effects. Fatality has occurred following overdose with very high doses.

Precaution

Aging 40 years or over. Blood passed from the bowel. Feeling sick or vomiting. Having lost appetite or weight

Half Life

The plasma half-life averages 0.8 hours for alverine and 5.7 hours for the active primary metabolite.

Elimination Route

High renal clearance of all metabolites indicating that they are eliminated by active renal secretion.

Pregnancy & Breastfeeding use

The safety of Spasmaverine Citrate during pregnancy and breastfeeding is not established. It is not recommended for use during pregnancy or breastfeeding.

Contraindication

Hypersensitivity to Spasmaverine Citrate or any of the other ingredients of the capsule, Having obstruction of the gut.

Special Warning

Spasmaverine Citrate is not suitable for children under 12 years old.

Acute Overdose

Spasmaverine Citrate can produce hypotension and Atropine-like toxic effects. Management is as for Atropine poisoning with supportive therapy for hypotension.