Spectinomicina 50% Chemifarma

Spectinomicina 50% Chemifarma Uses, Dosage, Side Effects, Food Interaction and all others data.

Spectinomicina 50% Chemifarma binds to 30S subunit of the bacterial ribosome, thus inhibiting protein synthesis. It has modest activity against a wide range of gm+ve and gm-ve organisms, though anaerobic organisms are mostly resistant.

Spectinomicina 50% Chemifarma is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.

Trade Name Spectinomicina 50% Chemifarma
Availability Discontinued
Generic Spectinomycin
Spectinomycin Other Names Actinospectacina, Espectinomicina, Spectinomicina, Spectinomycin, Spectinomycine, Spectinomycinum
Type
Formula C14H24N2O7
Weight Average: 332.3496
Monoisotopic: 332.158351132
Protein binding

Not significant

Groups Approved, Investigational, Vet approved
Therapeutic Class Miscellaneous Antibiotics
Manufacturer
Available Country Italy
Last Updated: September 19, 2023 at 7:00 am
Spectinomicina 50% Chemifarma
Spectinomicina 50% Chemifarma

Uses

Spectinomicina 50% Chemifarma Sterile Powder is used for the treatment of:

  • Acute gonorrheal urethritis and proctitis in the male
  • Acute gonorrheal cervicitis and proctitis in the female
  • Men and women with known recent exposure to gonorrhea should be treated as those known to have gonorrhea.

How Spectinomicina 50% Chemifarma works

Spectinomicina 50% Chemifarma is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action.

Dosage

Spectinomicina 50% Chemifarma dosage

Adults (Men and Women): Inject 5 ml intramuscularly for a 2 gm dose.This is also the recommended dose for patients being treated after failure of previous antibiotic therapy

Intramuscular injections should be made deep into the upper outer quadrant of the gluteal muscle.

Spectinomicina 50% Chemifarma Sterile 2 grams Powder: Reconstitute with 3.2 ml of the accompanying water for injection with 0.9% Benzyl alcohol. Shake vials vigorously immediately after adding diluent and before withdrawing dose.

Side Effects

The following reactions were observed during the single dose clinical trials: soreness at the injection site, urticaria, dizziness, nausea, chills, fever and insomnia

Toxicity

Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.

Precaution

The usual precautions should be observed with atopic individuals. Prescribing Spectinomicina 50% Chemifarma Sterile Powder in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria

Interaction

May result in lithium toxicity when used concurrently. May increase or prolong the neuromuscular blocking effect of atracurium.

Spectinomicina 50% Chemifarma Disease Interaction

Major: colitis

Elimination Route

Rapidly and almost completely absorbed after intramuscular injection.

Half Life

1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.

Pregnancy & Breastfeeding use

Pregnancy Category B. Since there are no controlled studies of Spectinomicina 50% Chemifarma in pregnant women, and because animal reproduction studies are not always predictive of human responses, Spectinomicina 50% Chemifarma should be used during pregnancy only if clearly needed.

Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Spectinomicina 50% Chemifarma is administered to a nursing woman.

Contraindication

The use of Spectinomicina 50% Chemifarma Sterile Powder is contraindicated in patients previously found hypersensitive to it.

Acute Overdose

Information on overdosage in humans is not available. Hemodialysis has been reported to aid in the removal of intravenously administered Spectinomicina 50% Chemifarma from the body.

Storage Condition

Store between 20-25°C. Reconstituted solution should be used within 24 hr after preparation.

FAQ

What is Spectinomicina 50% Chemifarma used for?

Spectinomicina 50% Chemifarma is an antibiotic. It fights bacteria in the body.
Spectinomicina 50% Chemifarma is used in the treatment of gonorrhea.
Spectinomicina 50% Chemifarma may also be used for purposes other than those listed here.

How should I take Spectinomicina 50% Chemifarma?

Spectinomicina 50% Chemifarma will be administered as an injection by a healthcare provider.

What are the common side effects of Spectinomicina 50% Chemifarma?

The common sde effects of Spectinomicina 50% Chemifarma are include:

  • nausea;

  • dizziness;

  • soreness at the injection site; or

  • fever.

Is Spectinomicina 50% Chemifarma safe during breastfeeding?

Do not use Spectinomicina 50% Chemifarma without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Is Spectinomicina 50% Chemifarma safe during pregnancy?

It is not known whether Spectinomicina 50% Chemifarma passes into breast milk. Do not take Spectinomicina 50% Chemifarma without first talking to your doctor if you are breast-feeding a baby.

How many days should I take Spectinomicina 50% Chemifarma?

A minimum of 10 days of therapy is recommended.

How do I give a Spectinomicina 50% Chemifarma injection?

Inject 5 mL intramuscularly for a 2-gram dose. This is also the recommended dose for patients being treated after failure of previous antibiotic therapy.

Can Spectinomicina 50% Chemifarma cure typhoid?

Effective Against Disease for Which No cure Was Known 3 doctors reports find of 5 Persons Treated During Experiments, 3 Were Cured by Philadelphia Physicians.

Can Spectinomicina 50% Chemifarma cure staphylococcus?

Spectinomicina 50% Chemifarma and Kanamycin were once effective against Staphylococcal infections. They have developed resistance by modifying enzymes, changing the ribosomal attachment sites and by actively pushing out the drug from the bacteria.

Is Spectinomicina 50% Chemifarma a plant?

Spectinomicina 50% Chemifarma formulations used in plant agriculture are produced using Streptomyces griseus subsp. griseus, which carries strA for self-resistance to the antibiotic.

Who should not take Spectinomicina 50% Chemifarma?

The risk is higher if you have kidney disease, if you are receiving high doses of this medication, if you use this drug for a long time, if you are an older adult (older than 60 years), or if you develop a severe loss of body water (become dehydrated).

Is Spectinomicina 50% Chemifarma an antifungal?

Spectinomicina 50% Chemifarma is an antibiotic antifungal drug, an antibiotic fungicide and a member of Spectinomicina 50% Chemifarma.

Is Spectinomicina 50% Chemifarma used for tuberculosis?

Spectinomicina 50% Chemifarma is an aminoglycoside antibiotic derived from Streptomyces griseus that is used in the treatment of tuberculosis and sensitive Gram-negative infections.

What bacteria does Spectinomicina 50% Chemifarma target?

Spectinomicina 50% Chemifarma is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria, and is therefore a useful broad-spectrum antibiotic.

Is Spectinomicina 50% Chemifarma effective against E coli?

Spectinomicina 50% Chemifarma treatment enhances the growth of E. coli by nitrate respiration.

Why is Spectinomicina 50% Chemifarma so effective?

Spectinomicina 50% Chemifarma is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome.

What happens if I miss a dose?

Since Spectinomicina 50% Chemifarma is usually administered as a single injection, missing dose is not likely to occur.

What happens if I overdose?

Seek emergency medical attention if an overdose of spectinomycin is suspected.
Symptoms of a spectinomycin overdose are not known.

*** Taking medicines without doctor's advice can cause long-term problems.
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