Sponge antiseptic with kanamycin (Kanamycin,Nitrofural,[Calcium chloride,Gelatine]) Uses, Dosage, Side Effects and more
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis.
Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.
| Trade Name | Sponge antiseptic with kanamycin (Kanamycin,Nitrofural,[Calcium chloride,Gelatine]) |
| Generic | Kanamycin + Nitrofural + [calcium Chloride + Gelatine] |
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| Available Country | Russia |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Kanamycin is in a group of drugs called aminoglycosides. It fights bacteria in the body. Kanamycin is used to treat serious infections caused by bacteria. Kanamycin may also be used for other purposes not listed in this medication guide.
Nitrofural is a topical antibacterial for the prevention and treatment of bacterial infections of the skin.
For the treatment of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
Sponge antiseptic with kanamycin (Kanamycin,Nitrofural,[Calcium chloride,Gelatine]) is also used to associated treatment for these conditions: Bacterial Infection caused by Acinetobacter species, Bacterial Infection caused by E. coli, Bacterial Infection caused by Enterobacter aerogenes, Bacterial Infection caused by Klebsiella Pneumoniae, Bacterial Infection caused by Proteus species, Bacterial Infection caused by Serratia marcescensSkin Infections
How Sponge antiseptic with kanamycin (Kanamycin,Nitrofural,[Calcium chloride,Gelatine]) works
Aminoglycosides like kanamycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.
Toxicity
Mild and reversible nephrotoxicity may be observed in 5 - 25% of patients. Amikacin accumulates in proximal renal tubular cells. Tubular cell regeneration occurs despite continued drug exposure. Toxicity usually occurs several days following initiation of therapy. May cause irreversible ototoxicity. Otoxocity appears to be correlated to cumulative lifetime exposure. Drug accumulation in the endolymph and perilymph of the inner ear causes irreversible damage to hair cells of the cochlea or summit of ampullar cristae in the vestibular complex. High frequency hearing is lost first with progression leading to loss of low frequency hearing. Further toxicity may lead to retrograde degeneration of the 8th cranial (vestibulocochlear) nerve. Vestibular toxicity may cause vertigo, nausea, vomiting, dizziness and loss of balance. Oral LD50 is 17500 mg/kg in mice, over 4 g/kg in rats, and over 3 g/kg in rabbits.
Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
Elimination Route
Kanamycin is rapidly absorbed after intramuscular injection and peak serum levels are generally reached within approximately one hour. Poor oral and topical absorption except with severe skin damage.
Well absorbed.
Half Life
2.5 hours
5 hours
