Stannsoporfin
Stannsoporfin Uses, Dosage, Side Effects, Food Interaction and all others data.
Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.
Stannsoporfin is a chemical compound being investigated for use as a medicament in the treatment of infant jaundice. Stannsoporfin is also known to inhibit heme metabolism in mammals, to control the rate of tryptophan metabolism in mammals, and to increase the rate at which heme is excreted by mammals.
Trade Name | Stannsoporfin |
Generic | Stannsoporfin |
Stannsoporfin Other Names | Stannsoporfin, Tin mesoporphyrin |
Type | |
Formula | C34H36Cl2N4O4Sn |
Weight | Average: 754.3 Monoisotopic: 754.113563 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications.
How Stannsoporfin works
Kernicterus is attributed to high levels of bilirubin, a by-product of heme metabolism. Bilirubin is a bile pigment, which is normally eliminated from the body after conversion into a water-soluble form by the liver. Stannsoporfin's mechanism of action specifically inhibits the enzyme that blocks the conversion of heme into bilirubin.
Elimination Route
Not absorbed orally
Half Life
3.8 hours following i.v. administration of 1 mumole per kg body weight
Innovators Monograph
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