Stem-cell Derived Extracellular Vesicle Products

Stem-cell Derived Extracellular Vesicle Products Uses, Dosage, Side Effects, Food Interaction and all others data.

Mesenchymal stem cells (MSCs) exert their therapeutic effects through multiple modalities, including paracrine factors such as exosomes. Exosomes are nanometer-sized, membrane-bound vesicles secreted for the purpose of cell-cell communication. Once secreted into extracellular fluid, exosomes are taken up by their target cells or carried to distant target sites. Various bioactive molecules (including lipids, proteins, mRNAs, and tRNAs) are used to enrich exosomes. While many contain a conserved set of proteins, they also carry unique tissue type-specific proteins. These products originate from multiple cellular types, including immunocytes, tumor cells, and mesenchymal stem cells (MSCs) originating from various tissues.

Exosomes from MSCs carry cytokines and growth factors, like TGFB1, IL-6, IL-10, and hepatocyte growth factor (HGF); all are shown to be immunomodulatory. These exosomes can also consist of VEGF and matrix metalloproteinase-9 (MMP-9) which aid in angiogenesis and tissue repair.

Trade Name Stem-cell Derived Extracellular Vesicle Products
Generic Stem-cell derived exosome vesicle products
Stem-cell derived exosome vesicle products Other Names DB-001, Stem-cell derived exosome vesicles, Stem-cell derived extracellular vesicle products, Stem-cell derived extracellular vesicles
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Stem-cell Derived Extracellular Vesicle Products
Stem-cell Derived Extracellular Vesicle Products

How Stem-cell Derived Extracellular Vesicle Products works

Exosomes are a novel cell-therapy currently investigated for the treatment of liver, kidney, cardiovascular, and neurological disease. They are messengers in intercellular communication through their ability to secrete bioactive lipids, proteins, and RNAs to target sites. As they can carry unique proteins and cytokines, exosomes are involved in both physiological and pathological processes. Therapeutically, MSC-derived exosomes can restore tissue homeostasis, and enable tissue recovery, repair, and regeneration.

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