Strepsils with Vitamin C (Sodium Ascorbate,Dichlorobenzyl Alcohol)
Strepsils with Vitamin C (Sodium Ascorbate,Dichlorobenzyl Alcohol) Uses, Dosage, Side Effects, Food Interaction and all others data.
Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.
In vitro studies with the combination of dichlorobenzyl alcohol and amylmetacresol have shown a virucidal against a number of viruses associated with the common cold which is observed by a reduction in the viral load. In clinical trials, administration of dichlorobenzyl alcohol lozenges has been shown to generate a reduced throat soreness and to provide pain relief and relief from difficulty in swallowing 5 minutes after administration. This effect can last for even 2 hours. The relief effect was shown to reach a steady-state after 45 minutes.
Table Of contents
| Trade Name | Strepsils with Vitamin C (Sodium Ascorbate,Dichlorobenzyl Alcohol) |
| Generic | Dichlorobenzyl Alcohol + Sodium Ascorbate |
| Type | |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United Kingdom |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dichlorobenzyl alcohol is a medication used to treat a sore throat.
Dichlorobenzyl alcohol in combination with Amylmetacresol is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.
Strepsils with Vitamin C (Sodium Ascorbate,Dichlorobenzyl Alcohol) is also used to associated treatment for these conditions: Mouth infection, Throat infections, Oral antisepsisCommon Cold, Cough, Fever, Flu caused by Influenza, Hoarseness, Pain, Throat irritation, Airway secretion clearance therapy, Nutritional supplementation, Vitamin supplementation
How Strepsils with Vitamin C (Sodium Ascorbate,Dichlorobenzyl Alcohol) works
The use of dichlorobenzyl alcohol has been related to its antibacterial, antiviral and local anesthetic properties. The local anesthetic action of dichlorobenzyl alcohol is thought to be due to a reduced sodium channel blockade. The antiseptic mechanism of action of dichlorobenzyl alcohol is not fully understood but it is thought to be related to a denaturation of external proteins and rearrangement of the tertiary structure proteins.
Toxicity
Fertility and mutagenicity studies do not indicate any effect driven by dichlorobenzyl alcohol. Overdose studies indicate that in systemic overdose there might be a presence of a CNS transitory stimulation followed by CNS and cardiovascular. Chronic administration is not recommended as it might alter the normal microbial balance of the throat. depression In rats, the reported LD50 is of about 2.7 g/kg when administered orally.
Volume of Distribution
This pharmacokinetic property has not been fully studied.
Elimination Route
Dichlorobenzyl alcohol is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes. The concentration in saliva after 120 minutes represents about 50% of the administered dose.
Half Life
This pharmacokinetic property has not been fully studied.
Clearance
This pharmacokinetic property has not been fully studied.
Elimination Route
In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose. After metabolism, dichlorobenzyl alcohol is excreted in the urine.
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