Streptomycin Sulfat
Streptomycin Sulfat Uses, Dosage, Side Effects, Food Interaction and all others data.
Aminoglycosides like Streptomycin Sulfat "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin Sulfat binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Although streptomycin originally had broad gram-negative and gram-positive coverage, its spectrum of activity has been significantly narrowed due to antibiotic resistance. Streptomycin Sulfats current spectrum of activity includes susceptible strains of Yersinia pestis, Francisella tularensis, Brucella, Calymmatobacterium granulomatis, H. ducreyi, H. influenza, K. pneumoniae pneumonia, E.coli, Proteus, A. aerogenes, K. pneumoniae, Enterococcus faecalis, Streptococcus viridans, Enterococcus faecalis, and Gram-negative bacillary bacteremia. Streptomycin Sulfat is not reliably active against pseudomonas aeruginosa.
Similar to other aminoglycosides, streptomycin is considered to have a narrow therapeutic index. Characteristic toxicities of streptomycin include nephrotoxicity and ototoxicity. Patients should be carefully monitored for early signs of hearing loss and vestibular dysfunction in order to prevent permanent damage to sensorineural cells. Neuromuscular blockade has also been rarely reported.
Trade Name | Streptomycin Sulfat |
Availability | Prescription only |
Generic | Streptomycin |
Streptomycin Other Names | Estreptomicina, Streptomicina, Streptomycin, Streptomyzin |
Related Drugs | doxycycline, ciprofloxacin, metronidazole, azithromycin, ceftriaxone, levofloxacin, vancomycin, gentamicin, Zithromax, Levaquin |
Type | Injection Powder 1 gram/vial |
Formula | C21H39N7O12 |
Weight | Average: 581.5741 Monoisotopic: 581.265669747 |
Groups | Approved, Vet approved |
Therapeutic Class | Aminoglycosides, Anti-Tubercular Antibiotics |
Manufacturer | Phapros Indonesia, Meiji, Kimia Farma |
Available Country | Indonesia |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Streptomycin Sulfat is used for the treatment of individuals with moderate to severe infections caused by susceptible strains of microorganisms in the specific conditions listed below:
Mycobacterium tuberculosis: The Advisory Council for the Elimination of Tuberculosis, the American Thoracic Society, and the Center for Disease Control recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid (INH), rifampin and pyrazinamide for initial treatment of tuberculosis unless the likelihood of INH or rifampin resistance is very low. The need for a fourth drug should be reassessed when the results of susceptibility testing are known. In the past when the national rate of primary drug resistance to isoniazid was known to be less than 4% and was either stable or declining, therapy with two and three drug regimens was considered adequate. If community rates of INH resistance are currently less than 4%, an initial treatment regimen with less than four drugs may be considered. Streptomycin Sulfat is also used for therapy of tuberculosis when one or more of the above drugs is contraused because of toxicity or intolerance. The management of tuberculosis has become more complex as a consequence of increasing rates of drug resistance and concomitant HIV infection. Additional consultation from experts in the treatment of tuberculosis may be desirable in those settings.
Non-tuberculosis infections: The use of streptomycin should be limited to the treatment of infections caused by bacteria which have been shown to be susceptible to the antibacterial effects of streptomycin and which are not amenable to therapy with less potentially toxic agents.
- Pasteurella pestis (plague)
- Francisella tularensis (tularemia)
- Brucella
- Calymmatobacterium granulomatis (donovanosis, granuloma inguinale)
- H. ducreyi (chancroid)
- H. influenzae (in respiratory, endocardial, and meningeal infections - concomitantly with another antibacterial agent)
- K. pneumoniae pneumonia (concomitantly with another antibacterial agent)
- E.coli, Proteus, A. aerogenes, K. pneumoniae, and Enterococcus faecalis in urinary tract infections
- Streptococcus viridans, Enterococcus faecalis (in endocardial infections - concomitantly with penicillin)
- Gram-negative bacillary bacteremia (concomitantly with another antibacterial agent)
To reduce the development of drug-resistant bacteria and maintain the effectiveness of streptomycin and other antibacterial drugs, streptomycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy
Streptomycin Sulfat is also used to associated treatment for these conditions: Bacteremia, Bacterial Infections caused by susceptible bacteria, Chancroid, Disseminated mycobacterium avium complex infection, Flu caused by Influenza, Granuloma Inguinale, Menière's Disease, Mycobacterium avium complex infection, Mycobacterium kansasii infection, Mycobacterium marinum infection, Plague, Pneumonia, Tuberculosis (TB), Tularemia, Urinary Tract Infection
How Streptomycin Sulfat works
There are 3 key phases of aminoglycoside entry into cells. The first “ionic binding phase” occurs when polycationic aminoglycosides bind electrostatically to negatively charged components of bacterial cell membranes including with lipopolysaccharides and phospholipids within the outer membrane of Gram-negative bacteria and to teichoic acids and phospholipids within the cell membrane of Gram-positive bacteria. This binding results in displacement of divalent cations and increased membrane permeability, allowing for aminoglycoside entry.
The second “energy-dependent phase I” of aminoglycoside entry into the cytoplasm relies on the proton-motive force and allows a limited amount of aminoglycoside access to its primary intracellular target - the bacterial 30S ribosome. This ultimately results in the mistranslation of proteins and disruption of the cytoplasmic membrane. Finally, in the “energy-dependent phase II” stage, concentration-dependent bacterial killing is observed. Aminoglycoside rapidly accumulates in the cell due to the damaged cytoplasmic membrane, and protein mistranslation and synthesis inhibition is amplified.
Hence, aminoglycosides have both immediate bactericidal effects through membrane disruption and delayed bactericidal effects through impaired protein synthesis; observed experimental data and mathematical modeling support this two-mechanism model.
Inhibition of protein synthesis is a key component of aminoglycoside efficacy. Structural and cell biological studies suggest that aminoglycosides bind to the 16S rRNA in helix 44 (h44), near the A site of the 30S ribosomal subunit, altering interactions between h44 and h45. This binding also displaces two important residues, A1492 and A1493, from h44, mimicking normal conformational changes that occur with successful codon-anticodon pairing in the A site. Overall, aminoglycoside binding has several negative effects including inhibition of translation, initiation, elongation, and ribosome recycling. Recent evidence suggests that the latter effect is due to a cryptic second binding site situated in h69 of the 23S rRNA of the 50S ribosomal subunit. Also, by stabilizing a conformation that mimics correct codon-anticodon pairing, aminoglycosides promote error-prone translation. Mistranslated proteins can incorporate into the cell membrane, inducing the damage discussed above.
Dosage
Streptomycin Sulfat dosage
Tularaemia:
- Adult: 1-2 g daily in divided doses for 7-14 days until the patient is afebrile for 5-7 days.
- Child: 15 mg/kg bid for at least 10-14 days. Max: 2 g daily
Bacterial endocarditis:
- Adult: Streptococcal endocarditis: 1 g bid for 1 wk, then 500 mg bid for the 2nd wk. Enterococcal endocarditis: 1 g bid for 2 wk then 500 mg bid for an additional 4 wk. Doses are given in combination with penicillin.
- Child: Enterococcal endocarditis: 20-30 mg/kg daily in 2 divided doses, in combination w/ penicillin.
- Elderly: Streptococcal endocarditis: >60 yr 500 mg bid for the entire 2 wk period.
Tuberculosis:
- Adult: 15 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose.
- Child: 20-40 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose.
- Elderly: >40 yr Max: 500-750 mg daily.
Plague:
- Adult: 2 g daily in 2 divided doses for a minimum of 10 days.
- Child: 30 mg/kg daily in 2-3 divided doses. Max: 2 g daily.
Bacteraemia, Brucellosis, Meningitis, Pneumonia, Urinary tract infections:
- Adult: For concomitant use with other agents and as 2nd line agent: 1-2 g daily in divided doses 6-12 hrly. Max: 2 g daily.
- Child: 20-40 mg/kg daily in divided doses 6-12 hrly.
Add 4.2 mL, 3.2 mL, or 1.8 mL of sterile water for inj to prepare a soln containing approx 200 mg, 250 mg, or 400 mg, respectively, of streptomycin per mL.
Side Effects
Neurotoxic reactions (e.g. vestibular and cochlear function disturbance, optic nerve dysfunction, peripheral neuritis, arachnoiditis, encephalopathy); paraesthesia of face, rash, fever, angioneurotic oedema, eosinophilia; exfoliative dermatitis, azotemia, leucopenia, thrombocytopenia, pancytopenia, haemolytic anaemia, muscular weakness, amblyopia.
Toxicity
The most common symptoms of streptomycin overdose are ototoxicity and vestibular impairment. Streptomycin Sulfat is also associated with nephrotoxicity which presents as mild elevations in blood urea, mild proteinuria, and excess cellular excretion. While in severe cases, streptomycin may lead to permanent hearing loss and vestibular dysfunction, any associated nephrotoxicity is typically transient. In cases of toxicity, streptomycin serum concentrations may be lowered with dialysis.
Precaution
Patient with neuromuscular disorders (e.g. myasthenia gravis), pre-existing vertigo, or hearing loss. Renal impairment. Elderly, childn. Pregnancy and lactation.
Interaction
Additive neurotoxic and nephrotoxic effect with neomycin, kanamycin, gentamicin, cefaloridine, paronomycin, viomycin, polymyxin B, colistin, tobramycin, and ciclosporin. Enhanced ototoxic and nephrotoxic effect with ethacrynic acid, mannitol, furosemide and possibly other diuretics. May enhance the resp depressant effect of neuromuscular blockers. Increased risk of nephrotoxicity with cephalosporins. Reduced excretion with NSAIDs.
Food Interaction
No interactions found.Streptomycin Sulfat Drug Interaction
Moderate: aspirin, ceftriaxoneUnknown: amoxicillin, sulfamethoxazole / trimethoprim, calcium / vitamin d, ciprofloxacin, albuterol / ipratropium, sulfamethoxazole / trimethoprim, multivitamin with minerals, acetaminophen, procaine penicillin, valproic acid, thiamine, cyanocobalamin, riboflavin, pyridoxine, ascorbic acid, cholecalciferol, phytonadione, levalbuterol
Streptomycin Sulfat Disease Interaction
Major: dehydration, neuromuscular blockade, ototoxicity, renal dysfunction
Elimination Route
Due to poor oral absorption, aminoglycosides including streptomycin are administered parenterally. Streptomycin Sulfat is available as an intramuscular injection, and in some cases may be administered intravenously. A peak serum concentration of 25-50 mcg/mL is achieved within 1 hour after intramuscular administration of 1 gram of streptomycin.
Half Life
Streptomycin Sulfats serum half-life is estimated to be 2.5 hours.
Elimination Route
Approximately 50% of streptomycin is eliminated in the urine within 24 hours after intravenous or intramuscular administration.
Pregnancy & Breastfeeding use
Streptomycin Sulfat can cause fetal harm when administered to a pregnant woman. Because streptomycin readily crosses the placental barrier, caution in use of the drug is important to prevent ototoxicity in the fetus. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Contraindication
Hypersensitivity to streptomycin and other aminoglycosides.
Special Warning
Renal Impairment: Dosage adjustment needed.
Storage Condition
Store between 15-30°C. Protect from light.
Innovators Monograph
You find simplified version here Streptomycin Sulfat
Streptomycin Sulfat contains Streptomycin see full prescribing information from innovator Streptomycin Sulfat Monograph, Streptomycin Sulfat MSDS, Streptomycin Sulfat FDA label
FAQ
What is Streptomycin Sulfat used for?
Streptomycin Sulfat belongs to a class of drugs known as aminoglycoside antibiotics.Streptomycin Sulfat works by killing the organisms that cause the infection. This drug may also be used to treat other serious infections along with other medications.
How to use Streptomycin Sulfat?
This medication is given by injection, usually into a muscle as directed by your doctor. When you start treatment for TB, it is usually given once a day or as directed by your doctor. It is important to change the location of the injection site daily to avoid problem areas under the skin.
What are the common side effects of Streptomycin Sulfat?
Common side effects of Streptomycin Sulfat are include:
- nausea,
- vomiting,
- stomach upset,
- loss of appetite,
- spinning sensation (vertigo),
- injection site reactions (pain, irritation, and redness),
- tingling or prickling sensation in the face,
- rash,
- fever,
- hives, and
- swelling (edema).
Is Streptomycin Sulfat safe during pregnancy?
Streptomycin Sulfat should not be used in pregnancy.
Is Streptomycin Sulfat safe during breastfeeding?
Streptomycin Sulfat is poorly excreted into breastmilk.
Can Streptomycin Sulfat cause deafness?
They found that Streptomycin Sulfat caused less ototoxicity than the other two drugs but that the size or frequency of dosage did not affect toxicity. Older age and cumulative dose were associated with an increased risk and median onset of hearing loss was 9 weeks in both patients treated daily and three times a week.
Why is Streptomycin Sulfat so effective?
Streptomycin Sulfat is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome.Streptomycin Sulfat is significant because it was the first antibiotic that could treat tuberculosis.
What causes Streptomycin Sulfat resistance?
Chromosomally acquired Streptomycin Sulfat resistance is frequently due to mutations in the gene encoding the ribosomal protein S12, rpsL.
Can Streptomycin Sulfat cure staphylococcus?
Aminoglycosides like Streptomycin Sulfat were once effective against Staphylococcal infections. They have developed resistance by modifying enzymes, changing the ribosomal attachment sites and by actively pushing out the drug from the bacteria.
Is Streptomycin Sulfat a strong antibiotic?
Streptomycin Sulfat is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria, and is therefore a useful broad-spectrum antibiotic.
How many days can Streptomycin Sulfat be taken?
Two grams of Streptomycin Sulfat daily in two divided doses should be administered intramuscularly. A minimum of 10 days of therapy is recommended.
When should I take Streptomycin Sulfat?
Streptomycin Sulfat is an antibiotic that is used to treat moderate to severe tuberculosis, pneumonia, E. coli, influenza, plague and other infections caused by certain bacteria.Streptomycin Sulfat may also be used for purposes not listed in this medication guid.
How do I take Streptomycin Sulfat?
Streptomycin Sulfat may be used in combination with Aureofungin sol for the control of bacterial and fungal diseases.
Who should not take Streptomycin Sulfat?
The risk is higher if you have kidney disease, if you are receiving high doses of this medication, if you use this drug for a long time, if you are an older adult (older than 60 years), or if you develop a severe loss of body water (become dehydrated).
Can Streptomycin Sulfat cause blindness?
Streptomycin Sulfat may causes blindness.A case of transient blindness occurring during long-term therapy with Streptomycin Sulfat and chloramphenicol is described.
Can Streptomycin Sulfat cause seizures?
Streptomycin Sulfat may cause seizures also with other side effects.
Can Streptomycin Sulfat cause hearing loss?
Streptomycin Sulfat may cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines.
Why is Streptomycin Sulfat so effective?
Streptomycin Sulfat is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome.
Can Streptomycin Sulfat cause hearing loss?
Streptomycin Sulfat may cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines.
Can Streptomycin Sulfat cause deafness to unborn baby?
The risk of deafness developing in the unborn child following the use of Streptomycin Sulfat during pregnancy remains uncertain.
When do you give Streptomycin Sulfat?
Streptomycin Sulfat is administered via injection daily or 5 days a week during the intensive phase, in the first two months of treatment.
Why is Streptomycin Sulfat not given orally?
Streptomycin Sulfat is not absorbed by the gastrointestinal track, and except for the treatment gastrointestinal infections, has to be administered by regular intramuscular injections, the usual dose being 1 g daily.
Is Streptomycin Sulfat an ototoxic?
Streptomycin Sulfat and gentamicin are primarily vestibulotoxic,
Why Streptomycin Sulfat is no longer used?
Streptomycin Sulfat was the first effective antituberculosis drug but is no longer a first-line drug as it has the disadvantage that it is not absorbed from the intestine and must therefore be given by intramuscular injection.