Stripod Ds

Stripod Ds Uses, Dosage, Side Effects, Food Interaction and all others data.

Stripod Ds Proxetil is an orally administered extended spectrum, semi-synthetic 3rd generation antibiotic of cephalosporin class. Like other β-lactam antibiotics it is a bactericidal drug that acts by inhibition of bacterial cell wall synthesis.

Stripod Ds is shown to be effective against most Gram positive and Gram negative bacteria, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.

Trade Name Stripod Ds
Availability Prescription only
Generic Cefpodoxime
Cefpodoxime Other Names Cefpodoxima, Cefpodoxime, Cefpodoximum
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin
Type Powder
Formula C15H17N5O6S2
Weight Average: 427.455
Monoisotopic: 427.062024681
Protein binding

22 to 33% in serum and from 21 to 29% in plasma.

Groups Approved, Vet approved
Therapeutic Class Third generation Cephalosporins
Manufacturer Striveo Healthcare Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Stripod Ds
Stripod Ds

Uses

Stripod Ds is used for the treatment of patients infected with susceptible strains of micro-organisms which include a wide range of gram-positive & gram-negative bacteria. As it is highly stable in presence of b-lactamase enzyme, so it is more effective against gram-positive bacteria than other 3rd generation oral Cephalosporins.

The susceptible organisms include gram-positive bacteria eg. S. aureus (including penicillinase producing strains), S. saprophyticus, S. pneumoniae, S. pyogenes, S. agalactiae, P. magnus and gram-negative bacteria eg. E. coli, K. pneumoniae, H. influenzae (including b-lactamase producer & Ampicillin resistant strains), M. catarrhalis, N. gonorrhoeae (including penicillinase producing strains), P. mirabillis, C. diversus, H. parainfluenzae, K. oxytoca, P. vulgaris, P. rettgeri.

Ximeprox is used for the following diseases:-

(1) Lower respiratory tract infection: Acute community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis; (2) Upper respiratory tract infection: Acute otitis media, Acute maxillary sinusitis, Pharyngitis, Tonsillitis; (3) Sexually transmitted diseases: Acute uncomplicated urethral & cervical gonorrhea, Acute ano-rectal infection in woman caused by N. gonorrhoeae; (4) Uncomplicated urinary tract infection: Cystitis, Pyuria; (5) Skin & soft tissue infections: Furuncle, Cellulitis, Subcutaneous abscess, infectious atheroma & periproctal abscess (6) Enteric fever.

Stripod Ds is also used to associated treatment for these conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Acute Otitis Media, Acute Sinusitis, Acute Tracheobronchitis, Acute maxillary sinusitis, Bacterial Infections, Bacterial Pneumonia, Community Acquired Pneumonia (CAP), Gonorrhea, Lower Respiratory Tract Infection (LRTI), Otitis Media (OM), Pharyngitis, Skin and Soft Tissue Infections, Streptococcal Pharyngitis, Streptococcal tonsillitis, Superinfection bacterial, Tonsillitis, Uncomplicated Urinary Tract Infections, Upper Respiratory Tract Infection, Uncomplicated Lower Respiratory Tract Infection (LRTI), Uncomplicated Upper Respiratory Tract Infection, Uncomplicated Urethritis gonococcal, Uncomplicated skin and subcutaneous tissue bacterial infections

How Stripod Ds works

Stripod Ds is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Stripod Ds is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Stripod Ds is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.

Dosage

Stripod Ds dosage

Ximeprox should be administered orally with food to enhance absorption. Ximeprox suspension may be given without regard to food.

Child :

15 days - 6 months : 4 mg/kg every 12 hours

6 months - 2 years : 40 mg every 12 hours

3 - 8 years : 80 mg every 12 hours

over 9 years : 100 mg every 12 hours

Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance <30 ml/min) the dosing intervals should be increased to 24 hourly.

Patients with liver cirrhosis: Stripod Ds proxetil pharmacokinetics in cirrhotic patients are similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Direction for Reconstitution of suspension:

For 100 ml suspension : Add 50 ml (10 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

For 50 ml suspension : Add 25 ml (5 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

For 50 ml DS suspension : Add 25 ml (5 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.

Note: Shake the suspension well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 10 days.

Side Effects

Stripod Ds has very few side effects. The side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children incidence of fungal skin rash is more than adults.

Precaution

In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of cefpodoxime proxetil should be reduced. Stripod Ds, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other broad spectrum antibiotics, prolonged use of cefpodoxime proxetil may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient's condition is essential.

Interaction

Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion with probenecid.

Food Interaction

  • Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.

[Moderate] ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of cefpodoxime proxetil tablets.

Following a 200 mg dose taken with food, the extent of absorption (mean AUC) was 21% to 33% higher and the mean peak plasma concentration (Cmax) 19% higher than under fasting conditions.

Time to peak concentration (Tmax) was not significantly different between fed and fasted states.

On the contrary, when a 200 mg dose of the suspension was taken with food, the mean AUC and Cmax were not significantly different than those under fasting conditions, although the rate of absorption was slower with food (48% increase in Tmax ).br>
MANAGEMENT: To ensure maximal oral absorption, cefpodoxime proxetil tablets should be administered with or immediately after a meal.

Elimination Route

Stripod Ds proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.

Half Life

2.09 to 2.84 hours

Elimination Route

Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.

Pregnancy & Breastfeeding use

There are no adequate and well-controlled studies on Stripod Ds proxetil use in pregnant woman, but it was found neither teratogenic nor embryocidal in animal trial. However, the drug should be used during pregnancy only if clearly needed. In nursing mother, Stripod Ds is excreted in breast milk & there is potential risk of serious reactions in nursing infants, so a decision should be made whether to discontinue breast feeding or to discontinue the drug.

Contraindication

Stripod Ds is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.

Renal Impairment: Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance <30 ml/min) the dosing intervals should be increased to 24 hourly.

Hepatic Impairment: The dosage does not require modification in cases of hepatic impairment.

Acute Overdose

Symptoms: Nausea, vomiting, epigastric distress and diarrhoea.

Management: Haemodialysis or peritoneal dialysis may be useful in the event of a serious toxic reaction particularly if renal function is compromised.

Interaction with other Medicine

Antacids: Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduces peak plasma level by 24% to 42% and the extent of absorption by 27% to 32% respectively.

Probenecid: Renal excretion of Stripod Ds proxetil was inhibited by Probenecid and resulted in an approximately 31% increase in AUC.

Nephrotoxic drugs: Close monitoring of renal function is advised when Stripod Ds proxetil is administered concomitantly with compounds of known Nephrotoxic potential.

Storage Condition

Capsule: Store below 30° C, protected from light and moisture.

Powder for suspension: Store below 25° C, protected from light and moisture.

After reconstitution: The suspension can be used within 7 days if be kept at room temperature and within 14 days if be kept in refrigerator (2° to 8° C). Always keep the bottle tightly closed.

Innovators Monograph

You find simplified version here Stripod Ds

Stripod Ds contains Cefpodoxime see full prescribing information from innovator Stripod Ds Monograph, Stripod Ds MSDS, Stripod Ds FDA label

FAQ

What Stripod Ds is used for?

Stripod Ds is used to treat certain infections caused by bacteria such as bronchitis, pneumonia; gonorrhea and infections of the skin, ear, sinuses, throat, tonsils, and urinary tract.

how safe Stripod Ds is?

Regarding safety, Stripod Ds was well tolerated by most patients. It has a tolerability profile similar to that of other oral cephalosporins, with gastrointestinal related symptoms and skin rash being the most frequently reported AEs.

How does Stripod Ds work?

Stripod Ds works by killing bacteria or preventing their growth.

What are the common side effects of Stripod Ds?

Common side effects of Stripod Ds are include:

  • abdominal pain.
  • anxiety.
  • back pain.
  • bloating.
  • body aches.
  • chest tightness.
  • chills.
  • confusion or weakness.

Is Stripod Ds safe during pregnancy?

Stripod Ds may be acceptable for use during pregnancy.Stripod Ds should only be given during pregnancy when need has been clearly established.

Is Stripod Ds safe during breastfeeding?

barnd is acceptable in nursing mothers.

Can I drink alcohol with Stripod Ds?

Stripod Ds has no known interactions with alcohol. However, alcohol should always be consumed with caution, especially when you are ill. 

Can I drive after taking Stripod Ds?

Stripod Ds can cause side effects like confusion and being less alert. If you experience any of these, do not drive any vehicle.

When should be taken of Stripod Ds?

Stripod Ds is usually taken every 12 hours for 5 to 14 days depending on the condition being treated. A single dose is given to treat gonorrhea. Take the tablet with food; the suspension can be taken with or without food. Take cefpodoxime at around the same times every day.

How long does Stripod Ds take to work?

Stripod Ds will start working right away to fight the infection in your body. You should start to feel better after 2 days, but continue to take all of your medication even if you feel better.

How long does Stripod Ds stay in my system?

Over the recommended dosing range approximately 29 to 33% of the administered Stripod Ds dose was excreted unchanged in the urine in 12 hours.

How long can I use Stripod Ds?

Stripod Ds is usually taken every 12 hours for 5 to 14 days depending on the condition being treated.

Is Stripod Ds bad for kidneys?

Kidney disease use with caution. Effects may be increased because of slower removal of the medicine from the body.

What happens if I miss a dose of Stripod Ds?

If you miss a dose of Stripod Ds, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Who should not take Stripod Ds?

You should not use Stripod Ds if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic.

Is Stripod Ds safe for liver?

Moderate Potential Hazard, Moderate plausibility. Cases of hepatitis have been reported with the use of certain cephalosporins.

Should Stripod Ds be taken with food?

Take the tablet with food, the suspension can be taken with or without food.

Can you overdose on Stripod Ds?

Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.

Does Stripod Ds make me tired?

Tired feeling, trouble breathing, unusual bleeding or bruising. unusual or unpleasant taste in your mouth.

*** Taking medicines without doctor's advice can cause long-term problems.
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