Sublifen

Sublifen Uses, Dosage, Side Effects, Food Interaction and all others data.

Sublifen (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Sublifen is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.

Sublifen is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Sublifen in humans has a rapid blood-brain equilibration half-time of 1 ± 1 minutes (mean ± SD) and a rapid onset of action.

Trade Name Sublifen
Availability Prescription only
Generic Remifentanil
Remifentanil Other Names Remifentanil, Remifentanilo, Remifentanyl
Related Drugs fentanyl, lidocaine, ketamine, hyoscyamine, propofol, glycopyrrolate
Type Powder
Formula C20H28N2O5
Weight Average: 376.4467
Monoisotopic: 376.199822016
Protein binding

70% (bound to plasma proteins)

Groups Approved
Therapeutic Class
Manufacturer Yichang humanwell pharmaceutical co,, ltd,
Available Country Philippines
Last Updated: September 19, 2023 at 7:00 am
Sublifen
Sublifen

Uses

Sublifen is an opioid analgesic used in anesthesia.

For use during the induction and maintenance of general anesthesia.

Sublifen is also used to associated treatment for these conditions: Immediate postoperative analgesia therapy, Induction and Maintenance of General Anesthesia, Monitored anesthesia care sedation

How Sublifen works

Sublifen is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.

Food Interaction

  • Avoid alcohol. Ingesting alcohol may increase the sedative and CNS depressant effects of remifentanil.

Sublifen Alcohol interaction

[Moderate] GENERALLY AVOID:

Ethanol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics.

Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills.

In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

Concomitant use of opioid analgesics with ethanol should be avoided.

Volume of Distribution

  • 350 mL/kg
  • 452 ± 144 mL/kg [neonates]
  • 223 ± 30.6 mL/kg [adolescents]

Half Life

1-20 minutes

Clearance

  • 40 mL/min/kg [young, healthy adults]

Elimination Route

Sublifen is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.

Innovators Monograph

You find simplified version here Sublifen

*** Taking medicines without doctor's advice can cause long-term problems.
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