Success
Success Uses, Dosage, Side Effects, Food Interaction and all others data.
Success is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Success is an insecticide based on a compound found in S. spinosa, a bacterial species. Success has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants.
Spinosyn A does not appear to directly interact with any known relevant insecticidal targets, but instead boasts a novel mechanism that resembles a GABA antagonist. Spinosyn A is also slightly more biologically active than spinosyn D.
| Trade Name | Success |
| Availability | Prescription only |
| Generic | Spinosad |
| Spinosad Other Names | Spinosad |
| Related Drugs | ivermectin topical, sodium chloride topical, permethrin topical, Elimite, acetic acid topical, Natroba, Nix Cream Rinse, Lice Treatment, RID |
| Type | |
| Formula | C83H132N2O20 |
| Weight | Average: 1477.963 Monoisotopic: 1476.937344658 |
| Protein binding | Not plasma protein bound if administered topically. |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Success is a pediculicide used topically to treat head lice.
Success is indicated for the topical treatment of head lice in children four years old and over and in adults.
Success is also used to associated treatment for these conditions: Head Lice Infestation
How Success works
Success is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. This combination causes neuronal hyperexcitation through mostly alteration of nicotinic acetylcholine receptors, which ultimately leads to lice paralysis and death.
Toxicity
Natroba contains benzyl alcohol, which should be avoided in neonates due to associated severe adverse effects and potential fatality. For use only on the scalp and associated hair. Avoid ingestion and contact with eyes. Success itself is not hazardous by the oral, dermal, ocular, or inhalational routes.
Food Interaction
- Take with or without food.
Success Disease Interaction
Volume of Distribution
No distribution if administered topically.
Elimination Route
Not absorbed if administered topically.
Innovators Monograph
You find simplified version here Success
