Sudafed Pe Childrens Decongestant
Sudafed Pe Childrens Decongestant Uses, Dosage, Side Effects, Food Interaction and all others data.
Sudafed Pe Childrens Decongestant is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Sudafed Pe Childrens Decongestant was granted FDA approval in 1939.
Sudafed Pe Childrens Decongestant is an alpha-1 adrenergic agonist that raises blood pressure, dilates the pupils, and causes local vasoconstriction. Ophthalmic formulations of phenylephrine act for 3-8 hours while intravenous solutions have an effective half life of 5 minutes and an elimination half life of 2.5 hours. Patients taking ophthalmic formulations of phenylephrine should be counselled about the risk of arrhythmia, hypertension, and rebound miosis. Patients taking an intravenous formulation should be counselled regarding the risk of bradycardia, allergic reactions, extravasation causing necrosis or tissue sloughing, and the concomitant use of oxytocic drugs.
| Trade Name | Sudafed Pe Childrens Decongestant |
| Availability | Rx and/or OTC |
| Generic | Phenylephrine |
| Phenylephrine Other Names | Fenilefrina, Phenylephrine, Phenylephrinum |
| Related Drugs | metoprolol, atenolol, diltiazem, dexamethasone, amiodarone, methylprednisolone, hydrocortisone, bisoprolol, epinephrine topical, epinephrine |
| Weight | 2.5mg/5ml, 10mg, tannate10mg, 10mg |
| Type | Oral liquid, oral tablet, oral tablet, chewable, extended release, oral tablet, disintegrating |
| Formula | C9H13NO2 |
| Weight | Average: 167.205 Monoisotopic: 167.094628665 |
| Protein binding | Data regarding the protein binding of phenylephrine in serum is not readily available. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sudafed Pe Childrens Decongestant is an alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
Sudafed Pe Childrens Decongestant injections are indicated to treat hypotension caused by shock or anesthesia, an ophthalmic formulation is indicated to dilate pupils and induce vasoconstriction, an intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include situations that require local blood flow restriction such as the treatment of priapism.
Sudafed Pe Childrens Decongestant is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Anorectal discomfort, Cold, Common Cold, Common Cold/Flu, Congestion of the Conjunctivas, Conjunctivitis allergic, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hemorrhoids, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia, Pollen Allergy, Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Shock, Cardiogenic, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Itchy throat, Minor aches and pains, Watery itchy eyes, Airway secretion clearance therapy, Antihistamine, Dilatation of the pupil, Vasoconstrictor in regional analgesia therapy
How Sudafed Pe Childrens Decongestant works
Sudafed Pe Childrens Decongestant is an alpha-1 adrenergic agonist that mediates vasoconstriction and mydriasis depending on the route and location of administration. Systemic exposure to phenylephrine also leads to agonism of alpha-1 adrenergic receptors, raising systolic and diastolic pressure as well as peripheral vascular resistance. Increased blood pressure stimulates the vagus nerve, causing reflex bradycardia.
Toxicity
Patients experiencing and overdose may present with headache, hypertension, reflex bradycardia, tingling limbs, cardiac arrhythmias, and a feeling of fullness in the head. Overdose may be treated by supportive care and discontinuing phenylephrine, chronotropic medications, and vasodilators. Subcutaneous phentolamine may be used to treat tissue extravasation.
Food Interaction
No interactions found.Sudafed Pe Childrens Decongestant Drug Interaction
Moderate: duloxetineUnknown: fexofenadine, diphenhydramine, loratadine, ubiquinone, dextromethorphan, omega-3 polyunsaturated fatty acids, cyclobenzaprine, fluticasone nasal, pregabalin, guaifenesin, acetaminophen, montelukast, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, alprazolam, ondansetron, cetirizine
Sudafed Pe Childrens Decongestant Disease Interaction
Major: cardiovascular diseaseModerate: BPH, diabetes, glaucoma
Volume of Distribution
The volume of distribution of phenylephrine is 340L.
Elimination Route
Sudafed Pe Childrens Decongestant is 38% orally bioavailable. Clinically significant systemic absorption of ophthalmic formulations is possible, especially at higher strengths and when the cornea is damaged.
Half Life
Intravenous phenylephrine has an effective half life of 5 minutes and an elimination half life of 2.5 hours.
Clearance
Sudafed Pe Childrens Decongestant has an average clearance of 2100mL/min.
Elimination Route
86% of a dose of phenylephrine is recovered in the urine with 16% as the unmetabolized drug, 57% as the inactive meta-hydroxymendelic acid, and 8% as inactive sulfate conjugates.
Innovators Monograph
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FAQ
What is Sudafed Pe Childrens Decongestant used for?
Sudafed Pe Childrens Decongestant is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. When taken orally as a decongestant, it relieves nasal congestion due to colds and hay fever.
How safe is Sudafed Pe Childrens Decongestant?
Sudafed Pe Childrens Decongestant is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label.
How does Sudafed Pe Childrens Decongestant work?
Sudafed Pe Childrens Decongestant works by directly stimulating alpha-1 adrenergic receptors in the arteries causing vasoconstriction.
What are the common side effects of Sudafed Pe Childrens Decongestant?
Mild upset stomach, trouble sleeping, dizziness, lightheadedness, headache, nervousness, shaking, or fast heartbeat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This product may reduce blood flow to your hands or feet, causing them to feel cold.
Is Sudafed Pe Childrens Decongestant safe during pregnancy?
Sudafed Pe Childrens Decongestant that's taken by mouth is not safe for pregnant women. Sudafed Pe Childrens Decongestant are generally not recommended during the first 13 weeks of pregnancy.
Is Sudafed Pe Childrens Decongestant safe during breastfeeding?
Sudafed Pe Childrens Decongestant an ingredient in pediatric cough and cold preparations, is considered safe. While excretion into breast milk is unknown, it is unlikely to be excreted into breast milk in large quantities due to its poor bioavailability.
Can I drink alcohol with Sudafed Pe Childrens Decongestant?
Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause confusion, dizziness, lightheadedness, and increased risk of falling
Can I drink alcohol with Sudafed Pe Childrens Decongestant?
This Sudafed Pe Childrens Decongestant may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and Sudafed Pe Childrens Decongestant.
How often can I take Sudafed Pe Childrens Decongestant?
Sudafed Pe Childrens Decongestant is usually taken every 4 hours as needed.
Can I take Sudafed Pe Childrens Decongestant on an empty stomach?
Take this Sudafed Pe Childrens Decongestant by mouth with or without food or as directed by your doctor. Taking it with food may decrease stomach upset.
How long does Sudafed Pe Childrens Decongestant take to work?
The decongestant effect of Sudafed Pe Childrens Decongestant in cold or flu remedies should be noticeable within 15 to 30 minutes, and the effects last less than 4 hours. A rapid increase in blood pressure is usually seen following an intravenous dose that persists for up to 20 minutes.
How long does Sudafed Pe Childrens Decongestant stay in my system?
The elimination half life of Sudafed Pe Childrens Decongestant is about 2.5 to 3.0 hours. The clinical effects of a single intravenous bolus dose of Sudafed Pe Childrens Decongestant are short lived and needs to be repeated every 10–15 minutes.
How long can I take Sudafed Pe Childrens Decongestant?
This Sudafed Pe Childrens Decongestant is for temporary use only. Do not use for more than 7 days in a row without first consulting your doctor. Sudafed Pe Childrens Decongestant nasal is usually used every 4 hours.
When should I stop taking Sudafed Pe Childrens Decongestant?
Stop using Sudafed Pe Childrens Decongestant and call your doctor at once if you have: fast, pounding, or irregular heartbeat; severe dizziness or nervousness; sleep problems (insomnia).
Who should not take Sudafed Pe Childrens Decongestant?
Do not use Sudafed Pe Childrens Decongestant if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
What happens if I miss a dose?
Since cold medicine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happen if I take too much Sudafed Pe Childrens Decongestant?
Taking too much Sudafed Pe Childrens Decongestant can be dangerous. It can make you restless or your heartbeat fast, and make you feel sick or vomit. You may also have difficulty peeing.
Will Sudafed Pe Childrens Decongestant affect my fertility?
Sudafed Pe Childrens Decongestant or pseudophedrine have any impact on fertility.
Does Sudafed Pe Childrens Decongestant cause heart palpitations?
Sudafed Pe Childrens Decongestant can cause heart palpitations or raise your blood pressure.
Can Sudafed Pe Childrens Decongestant affect my kidneys?
Sudafed Pe Childrens Decongestant can increase blood pressure and cause your heart and kidneys to work too hard.
