Sulfur Hexafluoride
Sulfur Hexafluoride Uses, Dosage, Side Effects, Food Interaction and all others data.
Sulfur Hexafluoride is an ultrasound contrast agent indicated for use•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric patients
Sulfur Hexafluoride provides useful echocardiographic signal intensity for two minutes after the injection. Sulfur Hexafluoride microspheres are destroyed and contrast enhancement decreases as the mechanical index increases (values of 0.8 or less are recommended).For ultrasonography of the liver, Sulfur Hexafluoride provides dynamic patterns of differential signal intensity enhancement between focal liver lesions and liver parenchyma during the arterial, portal venous, and late phase of signal intensity enhancement of the microvasculature.
| Trade Name | Sulfur Hexafluoride |
| Generic | Sulfur hexafluoride |
| Sulfur hexafluoride Other Names | hexafluoridosulfur, Sulfur fluoride, Sulfur hexafluoride, sulfur(6+) fluoride, sulfur(VI) fluoride, Sulphur hexafluoride |
| Weight | + |
| Type | Intravenous powder for injection |
| Formula | F6S |
| Weight | Average: 146.05 Monoisotopic: 145.962490152 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sulfur Hexafluoride is a medication used in ultrasound to enhance viewing of blood vessels and the urinary tract.
Echocardiography: Sulfur Hexafluoride is indicated for use in adult patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricularendocardial border. Ultrasonography of the Liver: Sulfur Hexafluoride is indicated for use with ultrasound of the liver in adult and pediatric patients to characterize focal liver lesions.
How Sulfur Hexafluoride works
Within the blood, the acoustic impedance of Lumason microspheres is lower than that of the surrounding non-aqueous tissue. Therefore, an ultrasound beam is reflected from the interface between the microspheres and the surrounding tissue. The reflected ultrasound signal provides a visual image that shows a contrast between the blood and the surrounding tissues.
Food Interaction
No interactions found.Volume of Distribution
In a study of healthy subjects, the mean values for the apparent steady-state volume of distribution of SF6 were 341 L and 710 L for Lumason doses of 0.03 mL/kg and 0.3 mL/kg, respectively. Preferential distribution to the lung is likely responsible for these values.
Elimination Route
The pharmacokinetic of the SF6 gas component of Lumason was evaluated in 12 healthy adult subjects (7 men and 5 women). After intravenous bolus injections of 0.03 mL/kg and 0.3 mL/kg of Lumason, corresponding to approximately 1 and 10 times the recommended doses, concentrations of SF6 in blood peaked within 1 to 2 minutes for both doses.
Half Life
The terminal half-life of SF6 in blood was approximately 10 minutes for the 0.3 mL/kg dose. (At the 0.03 mL/kg dose, terminal half-life could not be estimated.)
Elimination Route
The SF6 component of Lumason is eliminated via the lungs.
Innovators Monograph
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