Sulisou

Sulisou Uses, Dosage, Side Effects, Food Interaction and all others data.

Sulisou (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Sulisou is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decrease the formation of gallstones. It can also reduce the amount of other bile acids that can be harmful to liver cells when levels are elevated.

It acts by reducing levels of cholesterol in the bile, helping gallstones that are made predominantly of cholesterol to dissolve. Sulisou is ineffective with stones of a high calcium or bile acid content.

Trade Name Sulisou
Generic Chenodeoxycholic acid
Chenodeoxycholic acid Other Names Acide chenodeoxycholique, Acido chenodeoxicholico, Acidum chenodeoxycholicum, Anthropodeoxycholic acid, Anthropodesoxycholic acid, CDCA, Chenic acid, Chenocholic acid, Chenodeoxycholate, Chenodeoxycholic acid, Chenodesoxycholic acid, Chenodiol, Gallodesoxycholic acid
Type
Formula C24H40O4
Weight Average: 392.572
Monoisotopic: 392.292659768
Groups Approved
Therapeutic Class
Manufacturer
Available Country Taiwan
Last Updated: September 19, 2023 at 7:00 am
Sulisou
Sulisou

Uses

Sulisou is a bile acid used for the treatment of primary biliary cirrhosis.

Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.

Sulisou is also used to associated treatment for these conditions: Radiolucent Cholesterol gallstones

How Sulisou works

Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.

Toxicity

Hepatotoxic.

Food Interaction

No interactions found.

Elimination Route

Chenodiol is well absorbed from the small intestine.

Elimination Route

About 80% of its bacterial metabolite lithocholate is excreted in the feces.

Innovators Monograph

You find simplified version here Sulisou

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
http://classyfire.wishartlab.com/tax_nodes/C0000258
http://classyfire.wishartlab.com/tax_nodes/C0001445
http://classyfire.wishartlab.com/tax_nodes/C0000516
http://classyfire.wishartlab.com/tax_nodes/C0003238
http://classyfire.wishartlab.com/tax_nodes/C0003232
http://classyfire.wishartlab.com/tax_nodes/C0001661
http://classyfire.wishartlab.com/tax_nodes/C0001292
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16755
http://www.genome.jp/dbget-bin/www_bget?cpd:C02528
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMST04010032
http://www.hmdb.ca/metabolites/HMDB0000518
http://www.genome.jp/dbget-bin/www_bget?drug:D00163
http://www.genome.jp/dbget-bin/www_bget?cpd:C02528
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10133
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443291
https://www.chemspider.com/Chemical-Structure.9728.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21674
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2323
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=16755
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL240597
https://zinc.docking.org/substances/ZINC000003914808
http://www.pharmgkb.org/drug/PA165958403
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/JN3
https://www.drugs.com/cdi/chenodiol.html
https://en.wikipedia.org/wiki/Chenodeoxycholic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
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