Sulphapyridine

Sulphapyridine Uses, Dosage, Side Effects, Food Interaction and all others data.

Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.

Sulphapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulphapyridine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
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Trade Name	Sulphapyridine
Generic	Sulfapyridine
Sulfapyridine Other Names	2-Sulfanilamidopyridin, 2-Sulfanilamidopyridine, 2-Sulfanilylaminopyridine, 2-Sulfapyridine, N(1)-Pyridylsulfanilamide, Solfapiridina, Sulfapiridina, Sulfapyridin, Sulfapyridine, Sulfapyridinum, Sulphapyridine
Type
Formula	C₁₁H₁₁N₃O₂S
Weight	Average: 249.289 Monoisotopic: 249.057197301
Protein binding	Approximately 50% bound to plasma proteins.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Sulphapyridine is a sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum.

For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum

How Sulphapyridine works

Sulphapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.