Sunfree
Sunfree Uses, Dosage, Side Effects, Food Interaction and all others data.
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption. Its use in pharmaceutical and cosmetic formulations is approved by FDA.
Acts as a photoprotective agent that protects the skin by preventing and minimizing the damaging effects of ultraviolet (UV) rays of natural light. The cellular effects of UV irradiation include DNA damage, cell cycle arrest, immunological depression, apoptosis, and transcriptional changes .
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
| Trade Name | Sunfree |
| Generic | Octinoxate + Oxybenzone |
| Weight | octyl methoxycinnamate |
| Type | Lotion |
| Therapeutic Class | |
| Manufacturer | Gary Pharmaceuticals Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Octinoxate is a sunscreen agent found in sunscreens that absorbs UV rays.
As an active ingredient in sunscreens and lip balms. Used for protection against damaging effects of sun rays.
Oxybenzone is a sunscreen agent found in sunscreens that absorbs UV rays.
Used as an ingredient in sunscreen and other cosmetics.
Sunfree is also used to associated treatment for these conditions: SunburnSunburn
How Sunfree works
Absorbs UV-B (predominantly) and UV-A rays while accumulating in the outermost layer of the epidermis. Like any other photoprotective agents, octinoxate prevents the damage to cells and deoxyribonucleic acid (DNA) by reducing the p53 protein expression following UV exposure and also increases the skin's tolerability to UV rays .
Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin.
Toxicity
Slightly hazardous in case of skin contact, eye contact, ingestion and inhalation. Octinoxate may form reactive singlet oxygen species and induce anti-estrogenic effects . UV-induced molecular breakdown of octinoxate may interfere with cellular processes or induce oxidative damage in human skin . The NOAEL (no observed adverse effect level) is 450 mg/kg bw/day for fertility and reproductive performance, for systemic parental and developmental toxicity in Wistar rats .
Elimination Route
Can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk . The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men .
Elimination Route
Can be detected in urine in unchanged form .
In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine.
Innovators Monograph
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