Sunmark 12 Hour Allergy Relief
Sunmark 12 Hour Allergy Relief Uses, Dosage, Side Effects, Food Interaction and all others data.
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Sunmark 12 Hour Allergy Relief is an antihistamine that also induces anticholinergic and sedative effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.
| Trade Name | Sunmark 12 Hour Allergy Relief |
| Availability | Rx and/or OTC |
| Generic | Clemastine |
| Clemastine Other Names | Clemastina, Clemastine, Clemastinum |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, triamcinolone, Benadryl, Zyrtec, Xolair |
| Type | Tablet |
| Formula | C21H26ClNO |
| Weight | Average: 343.89 Monoisotopic: 343.170292166 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sunmark 12 Hour Allergy Relief is an antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
Sunmark 12 Hour Allergy Relief is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Angioedema, Common Cold, Urticaria
How Sunmark 12 Hour Allergy Relief works
Sunmark 12 Hour Allergy Relief is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Toxicity
Oral LD50 in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.
Food Interaction
- Avoid alcohol.
- Take with food.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Sunmark 12 Hour Allergy Relief Drug Interaction
Moderate: lorazepam, lorazepamUnknown: azithromycin, azithromycin, ubiquinone, ubiquinone, ferrous sulfate, ferrous sulfate, acetaminophen, acetaminophen, bioflavonoids, bioflavonoids, montelukast, montelukast, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Sunmark 12 Hour Allergy Relief Disease Interaction
Moderate: anticholinergic effects, asthma/COPD, cardiovascular, renal/liver disease
Elimination Route
Rapidly absorbed from the gastrointestinal tract.
Elimination Route
Urinary excretion is the major mode of elimination.
Innovators Monograph
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