Surac

Surac Uses, Dosage, Side Effects, Food Interaction and all others data.

The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced. Several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane.

Surac stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels.

Trade Name Surac
Availability Prescription only
Generic Proparacaine
Proparacaine Other Names Proximetacaina, Proxymetacaine, Proxymetacainum
Related Drugs lidocaine ophthalmic, Alcaine, Balanced Salt Solution, BSS, BSS Plus, Omidria
Type Eye Drops
Formula C16H26N2O3
Weight Average: 294.3892
Monoisotopic: 294.194342708
Groups Approved, Vet approved
Therapeutic Class Ocular perioperative drugs
Manufacturer Salvador Vision Tech
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Surac
Surac

Uses

Surac is used for procedures in which a topical ophthalmic anesthetic is used for: corneal anesthesia of short duration, e.g. tonometry, gonioscopy, removal of corneal foreign bodies, and for short corneal and conjunctival procedures. It is also used for use prior to surgical operations such as cataract extraction.

Surac is also used to associated treatment for these conditions: Local anesthesia therapy

How Surac works

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Surac may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.

Dosage

Surac dosage

Deep anesthesia as in cataract extraction: Instill 1 drop to the eye every 5 to 10 minutes for 5 to 7 doses.

Removal of sutures: Instill 1 or 2 drops to the eye 2 or 3 minutes before removal of stitches.

Removal of foreign bodies: Instill 1 or 2 drops to the eye prior to operating.

Tonometry: Instill 1 or 2 drops to the eye immediately before measurement.

Side Effects

Occasional temporary stinging, burning and conjunctival redness may occur with the use of Surac.

Precaution

Prolonged use of a topical ocular anesthetic is not recommended. It may produce permanent corneal opacification with accompanying visual loss.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Use in pregnancy: It is not known whether Surac can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Surac should be administered to a pregnant woman only if clearly needed.

Use in lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Surac is administered to a nursing mother.

Contraindication

Surac eye drops should be considered contraindicated in patients with known hypersensitivity to any of the ingredients of Surac Hydrochloride.

Special Warning

Pediatric Use: Safety and effectiveness of Surac ophthalmic solution in pediatric patients have been established. Use of Surac is supported by evidence from adequate and well-controlled studies in adults and children over the age of twelve, and safety information in neonates and other pediatric patients.

Geriatric Use: No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients.

Storage Condition

Store bottles under refrigeration at 2° to 8° C & protect from light. It is desirable that the contents should not be used more than 4 weeks after first opening of the bottle. If solution shows more than a faint yellow color, it should not be used. Keep bottle tightly closed.

Innovators Monograph

You find simplified version here Surac

Surac contains Proparacaine see full prescribing information from innovator Surac Monograph, Surac MSDS, Surac FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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