Sustain III
Sustain III Uses, Dosage, Side Effects, Food Interaction and all others data.
A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
Sustain III is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sustain III is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA.
| Trade Name | Sustain III |
| Generic | Sulfamethazine |
| Sulfamethazine Other Names | Sulfadimethyldiazine, Sulfadimethylpyrimidine, Sulfadimidina, Sulfadimidine, Sulfadimidinum, Sulfametazina, Sulfametazyny, Sulfamethazine, Sulfamezathine, Sulphadimethylpyrimidine, Sulphamethazine |
| Type | For animal use only |
| Formula | C12H14N4O2S |
| Weight | Average: 278.33 Monoisotopic: 278.083746402 |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Sustain III is an antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.
For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.
Sustain III is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Endometritis, Furuncle, Streptococcal Sore Throat, Ulcers, Urinary Tract Infection
How Sustain III works
Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.
Toxicity
Sustain III may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
Food Interaction
No interactions found.Elimination Route
Rapidly absorbed following oral administration.
Innovators Monograph
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