Synacthene Depot

Synacthene Depot Uses, Dosage, Side Effects, Food Interaction and all others data.

Synacthene Depot (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Synacthene Depot exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.

Cosyntropin exhibits the full corticosteroidogenic activity of natural ACTH. Various studies have shown that the biologic activity of ACTH resides in the N- terminal portion of the molecule and that the 1-20 amino acid residue is the minimal sequence retaining full activity. Partial or complete loss of activity is noted with progressive shortening of the chain beyond 20 amino acid residue. For example, the decrement from 20 to 19 results in a 70% loss of potency. The pharmacologic profile of Cosyntropin is similar to that of purified natural ACTH. It has been established that 0.25 mg of Cosyntropin will stimulate the adrenal cortex maximally and to the same extent as 25 units of natural ACTH. Cosyntropin has less immunogenic activity than ACTH because the amino acid sequence having most of the antigenic activity of ACTH, i.e., amino acids 25-39, is not present in cosyntropin. The extra-adrenal effects which natural ACTH and Cosyntropin have in common include increased melanotropic activity, increased growth hormone secretion and an adipokinetic effect. These are considered to be without physiological or clinical significance.

Synacthene Depot
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Synacthene Depot
Generic	Tetracosactide
Tetracosactide Other Names	ATCH (1-24), beta(1-24)-corticotrophin, Corticotropin tetracosapeptide, corticotropin-(1-24), Cosyntropin, Tetracosactida, Tetracosactide, Tetracosactrin
Type
Formula	C₁₃₆H₂₁₀N₄₀O₃₁S
Weight	Average: 2933.49 Monoisotopic: 2931.580641316
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Greece
Last Updated:	September 19, 2023 at 7:00 am

Uses

Synacthene Depot is a diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.

For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

Synacthene Depot is also used to associated treatment for these conditions: Acute Gouty Arthritis, Acute Rheumatic Fever, Adrenal Insufficiency, Ankylosing Spondylitis (AS), Bell's Palsy, Choroiditis, Conjunctivitis, Corneal Inflammation, Dermatitis exfoliative generalised, Dermatomyositis, Iritis, Lupus Erythematosus, Multiple sclerosis exacerbation, Nephrotic Syndrome, Ophthalmia, Sympathetic, Optic Neuritis, Panhypopituitarism, Pemphigus, Periarteritis nodosa, Psoriatic Arthritis, Rheumatoid Arthritis, Scleroderma, Still's Disease, Ulcerative Colitis, Uveitis, Acquired hemolytic jaundice

How Synacthene Depot works

Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.