Synvisc One Intra-articular Injection 48 mg/10 ml
Synvisc One Intra-articular Injection 48 mg/10 ml Uses, Dosage, Side Effects, Food Interaction and all others data.
2.25 mL glass syringe containing one 2 mL (16 mg) dose of hylan G-F 20. The contents of the syringe are sterile and nonpyrogenic.Hylan G-F is an elastoviscous high molecular weight fluid containing hylan A and hylan B polymers produced from chicken combs. Hylans are derivatives of hyaluronan (sodium hyaluronate). Synvisc One Intra-articular Injection 48 mg/10 ml is unique in that the hyaluronan is chemically crosslinked. Hyaluronan is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine.Hylan G-F is a gel-like mixture that comes in a syringe containing 6 mL (1 ½ teaspoon) and is injected into your knee. It is made up of hylan A fluid, hylan B gel, and salt water. Hylan A and hylan B are made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan), also known as sodium hyaluronate that comes from chicken combs. Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly.Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc One Intra-articular Injection 48 mg/10 ml is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc One Intra-articular Injection 48 mg/10 ml is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.
| Trade Name | Synvisc One Intra-articular Injection 48 mg/10 ml |
| Generic | Hylan G-F 20 |
| Weight | 48 mg/10 ml |
| Type | Intra-articular Injection |
| Therapeutic Class | Drugs for Osteoarthritis |
| Manufacturer | Synovia Pharma PLC. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Hylan G-F is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics, e.g., acetaminophen.
Pediatrics: The safety and effectiveness of Hylan G-F have not been established in pediatric patients. Pediatric patients are defined as patients ≤ 21 years of age.
Dosage
Synvisc One Intra-articular Injection 48 mg/10 ml dosage
Synvisc One Intra-articular Injection 48 mg/10 ml is administered by intra-articular injection once a week (one week apart) for a total of three injections. Strict aseptic administration technique must be followed.
- Using an 18- to 22-gauge needle, remove synovial fluid or effusion before each Synvisc One Intra-articular Injection 48 mg/10 ml injection.
- Do not use the same syringe for removing synovial fluid and for injecting Synvisc One Intra-articular Injection 48 mg/10 ml however the same 18- to 22-gauge needle should be used.
- Twist the tip cap before pulling it off, as this will minimize product leakage.
- To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub.
Side Effects
The most commonly reported adverse events associated with Synvisc One Intra-articular Injection 48 mg/10 ml are the following: Pain in the injected knee, Swelling in the injected knee, Joint effusion
Precaution
- The effectiveness of a single treatment cycle of less than three injections (2 mL each) of Synvisc One Intra-articular Injection 48 mg/10 ml has not been established.
- The safety and effectiveness of Synvisc One Intra-articular Injection 48 mg/10 ml in locations other than the knee and for conditions other than osteoarthritis have not been established.
- The safety and effectiveness of the use of Synvisc One Intra-articular Injection 48 mg/10 ml concomitantly with other intra-articular injectables have not been established.
- Use caution when injecting Synvisc One Intra-articular Injection 48 mg/10 ml into patients who are allergic to avian proteins, feathers, and egg products.
- The safety and effectiveness of Synvisc One Intra-articular Injection 48 mg/10 ml in severely inflamed knee joints have not been established.
- Strict aseptic administration technique must be followed.
- STERILE CONTENTS. The syringe is intended for single use. The contents of the syringe must be used immediately after its packaging is opened. Discard any unused Synvisc One Intra-articular Injection 48 mg/10 ml.
- Do not use Synvisc One Intra-articular Injection 48 mg/10 ml if package is opened or damaged. Store in original packaging (protected from light) at room temperature below 86°F (30°C). DO NOT FREEZE.
- Remove synovial fluid or effusion before each Synvisc One Intra-articular Injection 48 mg/10 ml injection.
- Synvisc One Intra-articular Injection 48 mg/10 ml should be used with caution when there is evidence of lymphatic or venous stasis in the leg to be injected.
Interaction
No information provided.
Pregnancy & Breastfeeding use
Pregnancy: The safety and effectiveness of Synvisc One Intra-articular Injection 48 mg/10 ml have not been established in pregnant women.
Nursing mothers: It is not known if Synvisc One Intra-articular Injection 48 mg/10 ml is excreted in human milk. The safety and effectiveness of Synvisc One Intra-articular Injection 48 mg/10 ml have not been established in lactating women.
Contraindication
Do not administer to patients with known hypersensitivity (allergy) to hyaluronan (sodium hyaluronate) preparations. Do not inject Hylan G-F in the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site
Storage Condition
Do not use Synvisc One Intra-articular Injection 48 mg/10 ml if the package has been opened or damaged. Store in original packaging (protected from light) at room temperature below 86°F (30°C). DO NOT FREEZE.
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