Tabitral

Tabitral Uses, Dosage, Side Effects, Food Interaction and all others data.

Tabitral is a highly potent corticosteroid. It is structurally related to clobetasol. Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis and corticosteroid responsive dermatoses.

Tabitral was granted FDA approval on 17 December 1990.

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Tabitral has a moderate duration of action as it is applied once or twice daily. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

Trade Name Tabitral
Generic Ulobetasol
Ulobetasol Other Names 21-chloro diflorasone, Halobetasol, Ulobetasol, Ulobétasol, Ulobetasolum
Type
Formula C22H27ClF2O4
Weight Average: 428.9
Monoisotopic: 428.1565934
Protein binding

Ulobetasol is likely bound to corticosteroid binding globulin in serum.

Groups Approved
Therapeutic Class
Manufacturer
Available Country Mexico
Last Updated: September 19, 2023 at 7:00 am
Tabitral
Tabitral

Uses

Tabitral is a lipocortin corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.

Tabitral cream and ointment are indicated in the treatment of inflammatory and pruritic corticosteroid responsive dermatoses. Tabitral lotion is indicated in the treatment of plaque psoriasis.

Tabitral is also used to associated treatment for these conditions: Psoriasis Vulgaris (Plaque Psoriasis), Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis

How Tabitral works

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.

Glucocorticoids inhibit phospholipase 2 and neutrophil apoptosis and demargination, resulting in decreased formation of arachidonic acid derivatives. They also inhibit NF-Kappa B and other inflammatory transcription factors while promoting anti-inflammatory genes like interleukin-10.

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

Toxicity

Data regarding acute overdoses of glucocorticoids are rare. Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency. Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.

Food Interaction

No interactions found.

Elimination Route

Tabitral lotion reaches a Cmax of 201.1 ± 157.5 pg/mL, with a Tmax of 3 hours, and an AUC of 1632 ± 1147 pg*h/mL. Absorption can be influenced by skin integrity, the vehicle used, inflammation, or disease processes.

Half Life

In vitro experiments show halobetasol propionate, a derivative of ulobetasol, has a half life of 33 minutes.

Elimination Route

Corticosteroids are eliminated predominantly in the urine.

Innovators Monograph

You find simplified version here Tabitral

*** Taking medicines without doctor's advice can cause long-term problems.
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