Tallimustine

Tallimustine Uses, Dosage, Side Effects, Food Interaction and all others data.

Tallimustine, a benzoyl mustard derivative of distamycin A, is an alkylating agent that binds to the minor groove of DNA. It's association with severe myelotoxicity lead to the end of its development in favour of α-halogenoacrylamide derivatives such as brostallicin, which have a favourable cytotoxicity/myelotoxicity ratio. Newer generations of DNA minor groove binding agents can more specifically recognize base pair sequences.

Tallimustine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Tallimustine
Generic	Tallimustine
Tallimustine Other Names	Tallimustine
Type
Formula	C₃₂H₃₈Cl₂N₁₀O₄
Weight	Average: 697.62 Monoisotopic: 696.2454551
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Tallimustine is an alkylating agent previously investigated for it's antitumor activity but was stopped due to severe myelotoxicity.

Tallimustine was being investigated for its use in treating tumors. Derivatives of tallimustine with similar DNA binding ability and reduced myelotoxicity are being investigated for their antitumor activity.

How Tallimustine works

Tallimustine binds to the minor groove of DNA while avoiding targets like glutathione. Currently, the mechanism of DNA minor groove binding agents is poorly understood. Though, they may act by directly inhibiting the interaction of protein and DNA.