Tantong

Uses

Tantong is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.

Tantong is also used to associated treatment for these conditions: Excess mucus or phlegm, Airway secretion clearance therapy

How Tantong works

Tantong, is an orally administered mucolytic agent. It is classified as a thiol derivative and produced for the management of symptoms caused by chronic obstructive bronchitis. Tantong contains sulfhydryl groups which are released after hepatic first-pass metabolism in the liver. Its active metabolites (3 in number) exert both mucolytic activity and scavenging activity against free radicals. Tantong acts to regulate the production of mucus in the airway and regulates its viscosity while enhancing mucociliary transport. This leads to an increase in expectoration. Tantong shows inhibition against the effects of free radicals from cigarette smoke. Clinical studies in patients with chronic obstructive lung disease (COPD) have shown that this drug is generally safe and well tolerated. Tantong 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol 30mg twice daily. Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo. Tantong is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild.

Dosage

Tantong dosage

The usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Tantong can be given up to 12 months or as directed by the physician. Tantong capsule may be taken with or without food.

Side Effects

Common side effect is epigastric pain. Other side effects include headache, cold, taste alterations, nausea, vomiting, diarrhea, angioedema and other skin allergic reactions.

Precaution

It should be used with caution in mild liver failure. In that case, should not exceed a dose of 300 mg per day.

Pregnancy & Breastfeeding use

The use of Tantong in pregnant or breast-feeding women is not recommended.

Contraindication

It is contraindicated to patients who have hypersensitivity to Tantong. It should not be used in patients with creatinine clearance <25 ml/min, or with severe liver failure.

Special Warning

Renal Impairment: CrCl <25 ml/min: Contraindicated.

Hepatic Impairment:

• Mild to moderate: Max: 300 mg daily.
• Severe: Contraindicated.

Storage Condition

Keep in a dry place away from light and heat. Keep out of reach of children

Innovators Monograph

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