Tardivex 40 mg

Tardivex 40 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Tardivex 40 mg
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Tardivex 40 mg
Generic	Valbenazine Tosylate
Weight	40 mg
Type
Therapeutic Class
Manufacturer	Everest Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	October 19, 2023 at 6:27 am

Uses

Treatment of adults with Tardive Dyskinesia.

Dosage

Tardivex 40 mg dosage

The initial dose is 40 mg once daily. After one week, increase the dose to the recommended dose of 80 mg once daily. Continuation of 40 mg once daily may be considered for some patients. Administer it orally with or without food.

Side Effects

Somnolence, QT Prolongation

Precaution

Valbenazine can cause somnolence. May impair the patient's ability to drive or operate hazardous machinery. Valbenazine may prolong the QT interval. For patients who are CYP2D6-poor metabolizers or are taking a strong CYP2D6 inhibitor, dose reduction may be necessary. Avoid use in patients with congenital long QT syndrome or with arrhythmias associated with a prolonged QT interval. No dosage adjustment is necessary for patients with mild to moderate renal impairment. Use is not recommended in patients with severe renal impairment.

Interaction

Concomitant use of Valbenazine with MAOIs may increase the concentration of monoamine neurotransmitters in synapses, potentially leading to an increased risk of adverse reactions such as serotonin syndrome, or attenuated treatment effect of Valbenazine. Avoid concomi-tant use of Valbenazine with MAOIs. Concomitant use of Valbenazine with strong CYP3A4 inhibitors increased the exposure (Cmax and AUC) to valbenazine and its active metabolite compared with the use of valbenazine alone. Reduce the dose when valbenazine is co-administered with a strong CYP3A4 inhibitor. Consider reducing the dose based on tolerability when valbenazine is coadministered with a strong CYP2D6 inhibitor. Concomitant use of strong CYP3A4 inducers with valbenazine is not recommended. Digoxin concentrations should be monitored when co-administering valbenazine with digoxin. Increased digoxin exposure may increase the risk of exposure related adverse reactions.

Pregnancy & Breastfeeding use

The limited available data on Valbenazine use in pregnant women are insufficient to inform a drug-associated risk. A woman should not breastfeed during treatment with valbenazine and for 5 days after the final dose.

Acute Overdose

The clinical trials involving valbenazine do not provide information regarding symptoms with overdose. No specific antidotes for valbenazine are known. In managing overdose, provide supportive care, including close medical supervision and monitoring, and consider the possibility of multiple drug involvement.