Taufon

Taufon Uses, Dosage, Side Effects, Food Interaction and all others data.

Taufon, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and meat. The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections composed by cristalline amino acids.

The diet supplements containing taurine are formulated as a well-tolerated nitrogen source for nutritional support. Administration of diet supplements regulates the level of plasma amino acid concentration, nitrogen balance, weight and serum protein concentration to reach normal values, thus improving the nutritional status.

Trade Name Taufon
Generic Taurine
Taurine Other Names Aminoethylsulfonic acid, Taurine, Taurineold
Type
Formula C2H7NO3S
Weight Average: 125.147
Monoisotopic: 125.014663785
Protein binding

Taurine is highly bound to plasma proteins and retained in the plasma fraction.

Groups Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country Georgia, Russia
Last Updated: September 19, 2023 at 7:00 am
Taufon
Taufon

Uses

Taufon is an ingredient found in mixture products indicated for nutritional support.

The use of diet supplements containing taurine is indicated for the nutritional support of infants and young pediatric patients requiring total parenteral nutrition via central or peripheral routes. The usage of diet supplements containing taurine prevents nitrogen and weight loss or to treat negative nitrogen balance in pediatric patients where the alimentary tract cannot be done through oral, gastrostomy or jejunostomy administration, there is impaired gastrointestinal absorption or protein requirements are substantially increased.

Taufon is also used to associated treatment for these conditions: Total parenteral nutrition therapy

How Taufon works

The diet supplements containing taurine function by replacing the missing nutriments in the body. Taufon, as a single agent, presents different functions like substrate for formation of bile salts, cell volume regulation, modulation of intracellular calcium, cytoprotection of central nervous system, etc.

Toxicity

The administration of taurine has been correlatefd to significant in the hypothalamus and the modification of neuroendocrine functions. Other than that, taurine administration in regular doses is reported by different articles and institutions to be safe.

Food Interaction

No interactions found.

Volume of Distribution

The distribution of taurine was studied under the two-compartment model and each one of the compartments gave a range for the volume of distribution of 299-353 ml/kg in compartment 1 and 4608-8374 ml/kg in compartment 2 in mice. Further studies in healthy indivudals gave a volume of distribution that ranged from 19.8 to 40.7 L.

Elimination Route

Oral administration of taurine was studied and it reported dose-dependent values of AUC, Cmax and tmax wherein a dose of 1-30 mg/kg ranged from 89-3452 mcg min/L, 2-15.7 mcg min/ml and 15 min respectively. Further studies in healthy individuals gave an AUC, Cmax and tmax in the range of 116-284.5 mg h/L, 59-112.6 mg/L and 1-2.5 h.

Half Life

Oral administration of taurine in healthy individuals gave a plasma elimination half-life that ranged from 0.7-1.4 h.

Clearance

The clearance rate of orally administered taurine was reported to be dose-dependent wherein a dose of 1 mg/kg it presents a clearance rate of 11.7 ml min/kg, 10 mg/kg generates a clearance rate of 18.7 ml min/kg and a dose of 30 mg/kg reports a clearance rate of 9.4 ml min/kg. Further studies in healthy individuals generate a clearance rate that ranged from 14 to 34.4 L/h.

Elimination Route

Taufon flows and gets distributed in veins and arteries and reports have observed the presence of a significant released of taurine in portally drained viscera, thus suggesting that the main elimination route of taurine is by the gut. This elimination route may be explained by the enterohepatic cycle of taurine.

Innovators Monograph

You find simplified version here Taufon

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0004434
http://classyfire.wishartlab.com/tax_nodes/C0000270
http://classyfire.wishartlab.com/tax_nodes/C0001179
http://classyfire.wishartlab.com/tax_nodes/C0001157
http://classyfire.wishartlab.com/tax_nodes/C0003311
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15891
http://www.hmdb.ca/metabolites/HMDB0000251
http://www.genome.jp/dbget-bin/www_bget?drug:D00047
http://www.genome.jp/dbget-bin/www_bget?cpd:C00245
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1123
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506189
https://www.chemspider.com/Chemical-Structure.1091.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50357220
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10337
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=507393
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL239243
https://zinc.docking.org/substances/ZINC000003809490
http://www.pharmgkb.org/drug/PA451590
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2379
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/TAU
https://en.wikipedia.org/wiki/Taurine
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