Technetium (99mTc) Pyrophosphate
Technetium (99mTc) Pyrophosphate Uses, Dosage, Side Effects, Food Interaction and all others data.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
Technetium (99mTc) Pyrophosphate collects in areas of altered osteogenesis and injured myocardium. It also has an affinity for red blood cells, enabling imaging of blood pools.
| Trade Name | Technetium (99mTc) Pyrophosphate |
| Generic | Technetium Tc-99m pyrophosphate |
| Technetium Tc-99m pyrophosphate Other Names | Technetium (99mTc) pyrophosphate, Technetium TC 99M Pyrophosphate |
| Type | |
| Formula | O7P2Tc |
| Weight | Average: 272.847 Monoisotopic: 272.81818089 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Technetium (99mTc) Pyrophosphate is a radiopharmaceutical diagnostic agent used for diagnostic imaging scans for the bones, heart, and gastrointestinal tract.
For use as a skeletal imaging agent used to demonstrate areas of altered osteogenesis, and a cardiac imaging agent used as an adjunct in the diagnosis of acute myocardial infarction . May also be used to image gated blood pools and detect gastrointetinal bleeding.
Technetium (99mTc) Pyrophosphate is also used to associated treatment for these conditions: Gastrointestinal Bleeding, Altered osteogenesis
How Technetium (99mTc) Pyrophosphate works
It is thought that technetium Tc-99m pyrophosphate is adsorbed onto the surface of amorphous calcium phosphate deposits , insoluble hydroxyapatite crystals, and possibly other organic macromolecules. This would result in selective localization to necrotic muscle tissue such as that of a myocardial infarction where calcium deposition has begun as a result of cell damage. In areas of altered osteogenesis where hydroxyapatite formation is actively occuring, the surface area to volume ratio is high and favors a greater amount of technetium Tc-99m pyrophosphate to the surface of the crystals than in other areas of bone where crystal formation is less active. The localization of technetium Tc-99m pyrophosphate to these areas allows for their specific radioimaging.
Toxicity
Adverse reactions such as flushing, hypotension, fever, chills, nausea, vomiting and dizziness, as well as hypersensitivity reactions such as itching and various skin rashes have been noted . Technetium (99mTc) Pyrophosphate is a radiopharmaceutical and carries the risk of radiation toxicity if inappropriately dosed.
Food Interaction
No interactions found.Elimination Route
1-2h after injection approximately 40-50% is localized to the skeleton and 0.01-0.02% per gram to acutely infarcted myocardium .
Elimination Route
Approximately 40% of the dose is excreted in the urine within 24h .
Innovators Monograph
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