Technetium Methylene Diphosphonate
Technetium Methylene Diphosphonate Uses, Dosage, Side Effects, Food Interaction and all others data.
Technetium (99mTc) medronic acid is a pharmaceutical product used in nuclear medicine imaging. It is composed of a technetium ion complexed with medronic acid, a type of bisphosphonate. Like other bisphosphonates used in the treatment of osteoporosis, medronic acid binds to the hydroxyapatite crystals within bone, and in this way localizes the drug to bone for delineation of areas of altered osteogenesis. Following intravenous injection, single photon emission computed tomography (SPECT) is performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99.
| Trade Name | Technetium Methylene Diphosphonate |
| Generic | Technetium Tc-99m medronate |
| Technetium Tc-99m medronate Other Names | 99m Tc medronate, 99m Tc-medronate, 99mTc medronate, 99mTc-medronate, AN-MDP, Cis-Mdp, Tc 99m Mdp, Tc-99m Mdp, Technetium (99mTc) medronic acid, Technetium (99mTc) Methylenediphosphonate, Technetium 99mTc medronic acid, Technetium methylene diphosphonate, Technetium Tc 99m medronate, Technetium Tc 99m medronic acid, Technetium Tc 99M Mpi Mdp |
| Type | |
| Formula | CH6O8P2Tc |
| Weight | Average: 305.906 Monoisotopic: 305.861006841 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Technetium Methylene Diphosphonate is a diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Technetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
Technetium Methylene Diphosphonate is also used to associated treatment for these conditions: Altered osteogenesis
Food Interaction
- Drink plenty of fluids. Void urine as frequently as possible after the examination to minimize excess radiation of the bladder.
Elimination Route
When injected intravenously, Technetium Tc 99m Medronate is rapidly cleared from the blood; about 50% of the dose is accumulated and retained by the skeleton, while the remaining 50% is excreted in the urine within 24 hours. About 10% of the injected dose remains in the blood at 1 hour post-injection, 5% at 2 hours, and less than 1% remains at 24 hours. Following intravenous administration of Technetium Tc 99m Medronate, skeletal uptake occurs as a function of blood flow to bone and bone efficiency in extracting the complex.
Half Life
Technetium Tc-99m decays by isomeric transition with a physical half-life of 6.02 hours.
Innovators Monograph
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