Technetium Tc 99m DISIDA
Technetium Tc 99m DISIDA Uses, Dosage, Side Effects, Food Interaction and all others data.
Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion. Following intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver or gallbladder is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. This is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a gamma ray. Liver and gallbladder imaging is enabled through attachment to mebrofenin as this molecule has high hepatic uptake and fast biliary excretion, resulting in improved hepatic imaging. More specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 transporters.
Currently available within a sterile kit, Tc-99m Mebrofenin is indicated for imaging of the liver and gallbladder.
| Trade Name | Technetium Tc 99m DISIDA |
| Generic | Technetium Tc-99m mebrofenin |
| Technetium Tc-99m mebrofenin Other Names | Technetium (99mTc) mebrofenin, Technetium Tc 99m diisopropyl-iminodiacetic acid, Technetium Tc 99m DISIDA, Technetium Tc 99m Mebrofenin |
| Type | |
| Formula | C15H19BrN2O5Tc |
| Weight | Average: 484.23 Monoisotopic: 483.05 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Technetium Tc 99m DISIDA is a diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
How Technetium Tc 99m DISIDA works
Technetium Tc 99m Mebrofenin has no known pharmacologic activity at the recommended doses. It is used as a diagnostic agent as Technetium-99m decays by isomeric transition to technetium-99 through the release of a detectable gamma ray.
Food Interaction
- Take on an empty stomach. Administer Technetium Tc 99m DISIDA at least 4 hours after food to avoid false positives caused by food stimulating emptying of the gallbladder.
Elimination Route
Visualisation in the liver could be detected by 5 minutes and maximum liver uptake occurred at 11 minutes post-injection. Hepatic duct and gallbladder visualization occurred by 10 to 15 minutes and intestinal activity was visualized by 30 to 60 minutes in subjects with normal hepatobiliary function The mean percent injected dose remaining in the blood at 10 minutes was 17%.
Half Life
Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours.
Clearance
Following intravenous administration in normal subjects, Technetium Tc 99m Mebrofenin was rapidly cleared from the circulation.
Elimination Route
The mean percent injected dose excreted in the urine during the first 3 hours was 1%.
Innovators Monograph
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