Telotristat

Telotristat Uses, Dosage, Side Effects, Food Interaction and all others data.

A tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat.

Trade Name	Telotristat
Availability	Prescription only
Generic	Telotristat
Telotristat Other Names	Telotristat
Related Drugs	Xermelo
Type
Formula	C25H22ClF3N6O3
Weight	Average: 546.94 Monoisotopic: 546.1394008
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Food Interaction

[Moderate] ADJUST DOSING INTERVAL: Food increases the systemic exposure to both telotristat ethyl and its active metabolite, telotristat.

Following administration of a single 500 mg dose of telotristat ethyl (twice the recommended dose) with a high-fat meal, telotristat ethyl peak plasma concentration (Cmax) and systemic exposure (AUC) were 112% and 264% higher, respectively, compared to administration under fasted conditions.

The Cmax and AUC values for telotristat were also increased by 47% and 33%, respectively.

The in vitro inhibitory potency of telotristat towards tryptophan hydroxylase has been shown to be approximately 29 times higher than that of the parent drug.
br> MANAGEMENT: Telotristat ethyl should be administered with food.

Telotristat Disease Interaction

Moderate: constipation, hepatic impairment, renal dysfunction

Innovators Monograph

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