Temusi

Temusi Uses, Dosage, Side Effects, Food Interaction and all others data.

Temusi (non-viral fibroblast growth factor 1; NV1FGF) is a recombinant DNA plasmid in a pCOR backbone allowing expression of human FGF1.

Trade Name Temusi
Generic Riferminogene pecaplasmid
Riferminogene pecaplasmid Other Names Non-viral fibroblast growth factor 1, NV1FGF, Riferminogene pecaplasmid
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Temusi
Temusi

Uses

Investigated for use/treatment in amputation (limb) and peripheral vascular disease.

How Temusi works

NV1FGF is a novel pCOR DNA plasmid–based gene delivery system for local expression of FGF-1. The pCOR plasmid backbone has several features that increase biosafety. These attributes include replication in only a narrow host range of laboratory, but not wild type, Escherichia coli strains, absence of an antibiotic-resistance gene, and lack of the potentially immunostimulatory sequence motifs found in ColE1 plasmids. Preclinical studies of intramuscular administration of NV1FGF have demonstrated that local expression of FGF-1 persists for several weeks. The angiogenic effect of NV1FGF was confirmed in the more severe animal model. The administration of NV1FGF in the hypercholesterolemic hamster model of hindlimb ischemia significantly enhanced the formation of large conductance vessels as well as small resistance arteries in ischemia-injured muscles.

Innovators Monograph

You find simplified version here Temusi


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