Terazosin Hydrochloride

Terazosin Hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.

Terazosin Hydrochloride
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Terazosin Hydrochloride
Generic	Terazosin Hydrochloride
Type
Therapeutic Class	Alpha adrenoceptor blocking drugs, BPH/ Urinary retention/ Urinary incontinence
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Uses

Terazosin Hydrochloride is indicated in- Single therapy is used to relieve from signs and symptoms of benign prostatic hyperplasia (BPH). For the treatment of hypertension.

Dosage

Terazosin Hydrochloride dosage

Benign Prostatic Hyperplasia- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day. Hypertension- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 2-10 mg administered once a day.

Side Effects

Postural hypotension is more commonly reported side effect. Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.

Precaution

First dose may cause hypotension (within 30-90 minutes). Therefore should be taken on retiring to bed. Caution should be observed when Terazosin is administered with other antihypertensive agents, avoid the possibility of significant hypotension. When adding Terazosin to a diuretic or other antihypertensive agent, dosage reduction and retitration may be necessary. The patients should be cautioned to avoid situation such as driving and hazardous tasks where injury could result due to syncope after initiation of Terazosin therapy.

Interaction

In patients receiving Terazosin plus ACE inhibitors or diuretics the proportion reporting dizziness or related side effects was greater than in the total population of Terazosin treated patients from clinical trials. Terazosin has been given without interaction with analgesics/anti-inflammatory, cardiac glycosides, hypoglycemic, antiarrhythmic, anxiolytics/sedatives, antibacterial, hormones/steroids and drugs used for gout.

Pregnancy & Breastfeeding use

The safety of Terazosin during pregnancy has not been established. So Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to mother and fetus. It is not known whether Terazosin is excreted in breast milk. As many drugs are excreted in breast milk, caution should be exercised when Terazosin is administered to a nursing mother.

Contraindication

Terazosin is contraindicated in patients known to be hypersensitive to Terazosin or its analogues.

Acute Overdose

Acute overdose may lead to acute hypotension, cardiovascular support is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in a supine position. At the same time expansion of plasma volume and noradrenergic vasopressor may also be needed.