Tetraethylammonium
Tetraethylammonium Uses, Dosage, Side Effects, Food Interaction and all others data.
Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium.
Tetraethylammonium is a vasodilator because it blocks autonomic ganglia and prevents signals carrying vasoconstrictor impulses from proceeding.
| Trade Name | Tetraethylammonium |
| Generic | Tetraethylammonium |
| Type | |
| Formula | C8H20N |
| Weight | Average: 130.2511 Monoisotopic: 130.159574645 |
| Groups | Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tetraethylammonium is an experimental drug with no approved indication.
Tetraethylammonium is also used to associated treatment for these conditions: Skin Infections, Bacterial
How Tetraethylammonium works
Tetraethylammonium's mechanism of action is still being investigated, but it is known that it blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors.
Toxicity
Studies in animals and humans have reported cases of serious muscle paralysis, which can lead to respiratory distress and death.
Elimination Route
Tetraethylammonium is eliminated by active renal tubular secretion by the cation transport system.
Innovators Monograph
You find simplified version here Tetraethylammonium
